MicroRNAs Regulation of Tumor Angiogenesis

Yamakuchi, Munekazu

doi:10.5772/26056

Cited by 1 publication

(1 citation statement)

References 106 publications

(89 reference statements)

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“…The miRNAs are a class of non-coding RNAs involved in the mRNA degradation or translation inhibition. It is known that different miRNAs could be involved in the regulation of the functions of endothelial vascular cells, [4] such as inflammation and oxidative stress. For example, miR-126 is expressed mainly in endothelial cells and can control vascular inflammation through the inhibition of vascular cell adhesion molecule 1 (VCAM1), playing an important role in the modulation of angiogenesis through the regulation of vascular endothelial growth factor (VEGF) and phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2)/p85 .…”

Section: Introductionmentioning

confidence: 99%

miRNA/Target Gene Profile of Endothelial Cells Treated with Human Triglyceride‐Rich Lipoproteins Obtained after a High‐Fat Meal with Extra‐Virgin Olive Oil or Sunflower Oil

Santiago‐Fernández

Martín‐Reyes

Bautista

et al. 2020

Molecular Nutrition Food Res

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Scope The effects of triglyceride‐rich lipoproteins (TRLs) on the miRNA expression of endothelial cells, which are very involved in atherosclerosis, according to the type of diet are not known. Methods and Results The differences between the effects of TRLs isolated from blood of subjects after a high‐fat meal with extra‐virgin olive oil (EVOO) and sunflower oil (SO) on the microRNA‐Seq profile related to atherosclerosis in human umbilical vein endothelial cells are analyzed. 28 upregulated microRNAs with EVOO‐derived TRLs, which can regulate 22 genes related to atherosclerosis, are found. 21 upregulated microRNAs with SO‐derived TRLs, which can regulate 20 genes related to atherosclerosis, are found. These microRNAs are mainly involved in angiogenesis, with a predominance of an anti‐angiogenic effect with EVOO‐derived TRLs. Other microRNAs upregulated with SO‐derived TRLs are involved in cardiovascular diseases. Pathways for the target genes obtained from the upregulated microRNA with EVOO‐derived TRLs are involved in lipid metabolism and inflammatory and defense response, while those with SO‐derived TRLs are involved in lipid metabolic process. Conclusion EVOO‐derived TRLs seem to produce a more atheroprotective profile than SO‐derived TRLs. This study provides alternative mechanisms on the protective role of EVOO against the atherogenic process through microRNA regulation in endothelial cells.

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Section: Introductionmentioning

confidence: 99%