MicroRNAs Related to Cognitive Impairment After Hearing Loss

Mun, Seog‐Kyun; Chae, Hyunkyu; Piao, Xian Yu; Lee, Hyun Jin; Kim, Young Kook; Oh, Seung Ha; Chang, Mun Seog

doi:10.21053/ceo.2019.01382

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…In the analysis of GSE45026, we only selected C57 mice for analysis, because C57 mice have a clear phenomenon of senile hearing loss. In previous studies, Mun found that the expression of miR-29b-3p was elevated in the cochlea of aged C57BL/6 mice [28], which was consistent with our analysis. For others, miR-29a-3p, miR-29c-3p and miR-124-3p were mainly related to cancer [29][30][31][32][33][34], AD [35,36], and miR-124-3p also related to neurogenesis [37,38] and depression [39], with no research related to hearing loss.…”

Section: Discusssupporting

confidence: 93%

Screening of key genes and miRNAs involved in age-related hearing loss

song¹,

Zhang²,

Sun³

et al. 2020

Preprint

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Background Age-related hearing loss (ARHL) is the most common sensory deficit and refers to the gradual loss of hearing function with age. We aimed to research the differential expression genes during the occur of ARHL and explore microRNAs that maybe regulate these genes. Methods Search the GEO data GSE6045, GSE35234, GSE62173, GSE45026 from NCBI's Gene Expression Omnibus database, and analyze in R. Normalize GEO data by RMA method in R, and use linear microarray data model (LIMMA) method in R to compare young and old mice to find differential genes and microRNAs. Results 109 up-regulated and 121 down-regulated important genes were identified respectively. Functional enrichment shows that they are significantly enriched in protein digestion and absorption, neuroactive ligand-receptor interaction, and PI3K-Akt signaling pathway. Among the top 20 Hub genes, 7 down-regulated genes (Col3a1, Col1a2, Sparc, Col4a2, Col2a1, Lox, Sparc, Ctgf) have verified targeted miRNAs, which have interaction with differential miRNAs of GSE45026. Finally, we designated miR-29a-3p, miR-29b-3p, miR-29c-3p, and miR-124-3p as key miRNAs involved in the development of age-related hearing loss. Conclusions These low expression genes of Col3a1, Col1a2, Sparc, Col4a2, Col2a1,Lox, Sparc, and Ctgf maybe key genes of ARHL, and probably regulated by miR-29a-3p, miR-29b-3p, miR-29c-3p, and miR-124-3p.

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Section: Discusssupporting

confidence: 93%

Screening of key genes and miRNAs involved in age-related hearing loss

song¹,

Zhang²,

Sun³

et al. 2020

Preprint

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“…We postulated that previous statin use may have a protective effect against hearing impairment. Hearing impairment in the adult population could have multiple etiologies, such as age-related degenerative processes, noise exposure, ototoxic drug exposure, smoking, adiposity, and chronic diseases 13 – 15 . To encompass all these types of hearing impairment, this study collected data from a nationally registered hearing-impaired population and compared the previous statin use in this population to that in the control population.…”

Section: Introductionmentioning

confidence: 99%

Association between statin medication and hearing impairment in a national health screening cohort

Kim

Lee

Min

et al. 2021

Sci Rep

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This study aimed to investigate the association of previous stain use with hearing impairment in an adult population. Data from the ≥ 40-year-old population in the Korean National Health Insurance Service Health Screening Cohort were used. The hearing impairment group was classified based on the national registry of hearing-impaired persons. Control participants were randomly selected and matched for age, sex, income, and region of residence. The number of days of statin prescription during the 2 years before the diagnosis of hearing impairment was compared between the hearing impairment group and the control group using conditional logistic regression analysis. Additional analyses were conducted according to age and sex. The number of days of previous statin use was not different between the hearing impairment group and the control group (adjusted odds ratio [aOR] = 0.94, 95% confidence interval (CI) = 0.86–1.02, P = 0.118). According to age, in the ≥ 70-year-old group, those with hearing impairment had 11% lower rates of previous statin use than those in the control group (aOR = 0.89, 95% CI = 0.80–0.99, P = 0.039). According to sex, in the male group, 12% lower rates of previous statin use were observed among those with hearing impairment than among those in the control group (aOR = 0.88, 95% CI = 0.79–0.99, P = 0.037). Previous statin use might have an effect on reducing the prevalence of hearing impairment in elderly individuals and men.

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“…In addition, recent studies have shown a relationship between cognitive decline and miRNAs in AD. In a rat model of AD, several miRNAs were found to be involved in cognitive deficits after hearing loss [ 10 ]. Another study using aged Tg4-42 mice, a sporadic AD model revealed alterations in hippocampal miRNAs after memory decline [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Dysregulation in the Hippocampus of Rats with Noise‐Induced Hearing Loss

Kim

Lee

et al. 2021

Oxidative Medicine and Cellular Longevity

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Although hippocampal changes due to noise-induced hearing loss have been suggested, little is known about the miRNA levels due to these hippocampal changes. Three-week-old Sprague-Dawley rats were divided into noise and control groups ( n = 20 per group). The noise group rats were exposed to white Gaussian noise (115 dB SPL, 4 hours per day) for three days. One day after noise exposure, the hippocampi of rats were harvested and miRNA expressions were analyzed using the Affymetrix miRNA 4.0 microarray ( n = 6 per group). The predicted target genes of each miRNA were retrieved, and the pathways related to the predicted target genes were analyzed. miR-758-5p, miR-210-5p, miR-370-5p, miR-652-5p, miR-3544, miR-128-1-5p, miR-665, miR-188-5p, and miR-874-5p expression increased in the hippocampal tissue of the noise group compared to that in the control group. The overlapping predicted target genes included Bend4, Creb1, Adcy6, Creb5, Kcnj9, and Pten. The pathways related to these genes were the estrogen signaling pathway, vasopressin-regulated water reabsorption, thyroid hormone synthesis, aldosterone synthesis and secretion, insulin secretion, circadian entrainment, insulin resistance, cholinergic synapse, dopaminergic synapse, cGMP-PKG signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway, and AMPK signaling pathway. miR-448-3p, miR204-5p, and miR-204-3p expression decreased in the hippocampal tissue of the noise group compared to that in the control group. The overlapping predicted target genes of these three miRNAs were Rps6kas, Nfactc3, Rictor, Spred1, Cdh4, Cdh6, Dvl3, and Rcyt1b. Pathway analysis suggested that the Wnt signaling pathway is related to Dvl3 and Nfactc3. Noise-induced hearing loss dysregulates miR-758-5p, miR210-5p, miR370-5p, miR-652-5p, miR-3544, miR-128-1-5p, miR-665, miR-188-5p, miR-874-5p, miR-448-3p, miR-204-5p, miR-204-3p, and miR-140-5p expression in the hippocampus. These miRNAs have been predicted to be associated with hormonal, inflammatory, and synaptic pathways.

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MicroRNAs Related to Cognitive Impairment After Hearing Loss

Cited by 10 publications

References 24 publications

Screening of key genes and miRNAs involved in age-related hearing loss

Screening of key genes and miRNAs involved in age-related hearing loss

Association between statin medication and hearing impairment in a national health screening cohort

MicroRNA Dysregulation in the Hippocampus of Rats with Noise‐Induced Hearing Loss

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