MicroRNAs, small regulatory elements with significant effects on human implantation: a review

Azizi, Elham; Mofarahe, Zahra Shams; Naji, Mohammad

doi:10.1007/s10815-023-02735-w

Cited by 5 publications

(2 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of EVs can also be driven by cargo release in the epithelial cell membrane or inside the cell by binding to the ER. It is known that miRNAs secreted by blastocysts modulate the different cellular processes related to implantation [95]. Previously, we showed that trophoblast-derived miRNAs can be packaged in EVs and partly regulate gene expression in endometrial epithelial cells using the same in vitro model [13].…”

Section: Discussionmentioning

confidence: 97%

Secretory Proteomic Responses of Endometrial Epithelial Cells to Trophoblast-Derived Extracellular Vesicles

Muhandiram

Dissanayake

Orro

et al. 2023

IJMS

View full text Add to dashboard Cite

Synchronized crosstalk between the embryo and endometrium during the periconception period is integral to pregnancy establishment. Increasing evidence suggests that the exchange of extracellular vesicles (EVs) of both embryonic and endometrial origin is a critical component of embryo–maternal communication during peri-implantation. Here, we investigated whether embryonic signals in the form of EVs can modulate the endometrial epithelial cell secretome. Receptive endometrial analog RL95-2 cells were supplemented with trophoblast analog JAr cell-derived EVs, and the secretory protein changes occurring in the RL95-2 cells were analyzed using mass spectrometry. EVs of non-trophoblastic origin (HEK 293 cells) were used as the control EV source to supplement endometrial cells. Trophoblast cell-derived EVs enriched endometrial epithelial cell secretions with proteins that support embryo development, attachment, or implantation, whereas control EVs were unable to induce the same effect. The present study suggests that embryonic signals in the form of EVs may prime receptive endometrial epithelial cells to enrich their secretory proteome with critical proteomic molecules with functional importance for periconception milieu formation.

show abstract

Section: Discussionmentioning

confidence: 97%

Secretory Proteomic Responses of Endometrial Epithelial Cells to Trophoblast-Derived Extracellular Vesicles

Muhandiram

Dissanayake

Orro

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Among these miRNAs that influence STAT3 expression, we chose four specific miRNA SNPs: miR-218-2 rs11134527 G>A, miR-34a rs2666433 G>A, miR-34a rs6577555 C>A, and miR-130a rs731384 G>A. These miRNAs were of particular interest due to their potential connections with implantation [13]. Subsequently, we assessed the frequencies of these miRNA SNPs in RIF patients and control subjects within the Korean population.…”

Section: Introductionmentioning

confidence: 99%

Genetic Correlation of miRNA Polymorphisms and STAT3 Signaling Pathway with Recurrent Implantation Failure in the Korean Population

Lee,

Ahn,

Kwon

et al. 2023

IJMS

View full text Add to dashboard Cite

The growing prevalence of in vitro fertilization-embryo transfer procedures has resulted in an increased incidence of recurrent implantation failure (RIF), necessitating focused research in this area. STAT3, a key factor in maternal endometrial remodeling and stromal proliferation, is crucial for successful embryo implantation. While the relationship between STAT3 and RIF has been studied, the impact of single nucleotide polymorphisms (SNPs) in miRNAs, well-characterized gene expression modulators, on STAT3 in RIF cases remains uncharacterized. Here, we investigated 161 RIF patients and 268 healthy control subjects in the Korean population, analyzing the statistical association between miRNA genetic variants and RIF risk. We aimed to determine whether SNPs in specific miRNAs, namely miR-218-2 rs11134527 G>A, miR-34a rs2666433 G>A, miR-34a rs6577555 C>A, and miR-130a rs731384 G>A, were significantly associated with RIF risk. We identified a significant association between miR-34a rs6577555 C>A and RIF prevalence (implantation failure [IF] ≥ 2: adjusted odds ratio [AOR] = 2.264, 95% CI = 1.007–5.092, p = 0.048). These findings suggest that miR-34a rs6577555 C>A may contribute to an increased susceptibility to RIF. However, further investigations are necessary to elucidate the precise mechanisms underlying the role of miR-34a rs6577555 C>A in RIF. This study sheds light on the genetic and molecular factors underlying RIF, offering new avenues for research and potential advancements in the diagnosis and treatment of this complex condition.

show abstract

Role of HOXA10 in pathologies of the endometrium

Mishra,

Modi

2024

Rev Endocr Metab Disord

View full text Add to dashboard Cite

MicroRNAs, small regulatory elements with significant effects on human implantation: a review

Cited by 5 publications

References 101 publications

Secretory Proteomic Responses of Endometrial Epithelial Cells to Trophoblast-Derived Extracellular Vesicles

Secretory Proteomic Responses of Endometrial Epithelial Cells to Trophoblast-Derived Extracellular Vesicles

Genetic Correlation of miRNA Polymorphisms and STAT3 Signaling Pathway with Recurrent Implantation Failure in the Korean Population

Role of HOXA10 in pathologies of the endometrium

Contact Info

Product

Resources

About