MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

Angajala, Anusha; Raymond, Hughley; Muhammad, Aliyu; Ahmed, Md Shakir Uddin; Haleema, Saadia; Haque, Monira; Wang, Honghe; Campbell, Moray J.; Martini, Rachel; Karanam, Balasubramanian; Kahn, Andrea G.; Bedi, Deepa; Davis, Melissa B.; Tan, Ming; Dean-Colomb, Windy; Yates, Clayton

doi:10.1038/s41598-022-26000-9

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…MiRNA profiling of the TNBC tumor cells (and of several other types of tumors) can vary according to the populational group studied [20,26,[39][40][41][42][43][44]. Most of the data are, however, in the comparison of NHW to AA TNBC patients [26,40,[44][45][46][47]. In our previous study, we reported that ancestrally characterized AA patients, when compared to NHW, exhibited distinct patterns of copy number alterations (CNAs) and miRNA expression profiles in both their TNBC and non-TNBC tumor tissues [44].…”

Section: Introductionmentioning

confidence: 99%

Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Almohaywi,

Sugita,

Centa

et al. 2023

IJMS

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Among patients with triple-negative breast cancer (TNBC), several studies have suggested that deregulated microRNA (miRNA) expression may be associated with a more aggressive phenotype. Although tumor molecular signatures may be race- and/or ethnicity-specific, there is limited information on the molecular profiles in women with TNBC of Hispanic and Latin American ancestry. We simultaneously profiled TNBC biopsies for the genome-wide copy number and miRNA global expression from 28 Latina women and identified a panel of 28 miRNAs associated with copy number alterations (CNAs). Four selected miRNAs (miR-141-3p, miR-150-5p, miR-182-5p, and miR-661) were validated in a subset of tumor and adjacent non-tumor tissue samples, with miR-182-5p being the most discriminatory among tissue groups (AUC value > 0.8). MiR-141-3p up-regulation was associated with increased cancer recurrence; miR-661 down-regulation with larger tumor size; and down-regulation of miR-150-5p with larger tumor size, high p53 expression, increased cancer recurrence, presence of distant metastasis, and deceased status. This study reinforces the importance of integration analysis of CNAs and miRNAs in TNBC, allowing for the identification of interactions among molecular mechanisms. Additionally, this study emphasizes the significance of considering the patients ancestral background when examining TNBC, as it can influence the relationship between intrinsic tumor molecular characteristics and clinical manifestations of the disease.

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Section: Introductionmentioning

confidence: 99%

Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Almohaywi,

Sugita,

Centa

et al. 2023

IJMS

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“…Over 200 AAW-and CAW-INBC candidate biomarkers identified. Over the past decade, significant efforts have been made to identify prognostic biomarkers specific to AAW-TNBCs and CAW-TNBCs, resulting in the discovery of over 200 potential peptide biomarkers [67][68][69][70][71][72][73][74][75], and even encompassing metabolites and non-coding RNAs [76,77]. Despite this progress, these previous studies have faced considerable limitations, primarily due to the scarcity of AAW-TNBC cases, which hinders the determination of prognostic markers.…”

Section: Resultsmentioning

confidence: 99%

Updated Biomarkers for TNBC in African vs. Caucasian American Women

Croft,

Quintanar,

Zhang

2023

Preprint

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Introduction: Breast cancer, especially triple-negative breast cancer (TNBC), is a significant concern in the US, being the most common cancer among women and the second leading cause of cancer-related deaths. TNBC lacks crucial receptors targeted in other breast cancer types, leading to a poor prognosis and limited treatment options due to its aggressive and heterogeneous nature. Significance: African American women (AAW) with TNBC face higher mortality rates and more aggressive disease compared to Caucasian American women (CAW). Despite efforts to find biomarkers specific to AAW and CAW with TNBC, limited sample availability and data resources have been obstacles. Methods: In our study, we examined 237 candidate peptide biomarkers using publicly available data. Results: identify 23 unique prognostic biomarkers. These biomarkers accurately assess patient conditions based on race-specific gene expression patterns, holding potential to address racial disparities in TNBC treatment. Conclusion: Overall, our research sheds light on how racial genetic profiles influence TNBC prognosis and treatment efficacy. The identified prognostic biomarkers pave the way for future studies addressing TNBC racial disparities and personalized treatment approaches.

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The 30th Annual Prostate Cancer Foundation Scientific Retreat Report

Miyahira,

Soule

2024

The Prostate

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BackgroundThe 30th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held at the Omni La Costa Resort in Carlsbad, CA, from October 26 to 28, 2023. A hybrid component was included for virtual attendees.MethodsThe Annual PCF Scientific Retreat is a leading international scientific conference focused on pioneering, unpublished, and impactful studies across the spectrum of basic through clinical prostate cancer research, as well as research from related fields with significant potential for improving prostate cancer research and patient outcomes.ResultsThe 2023 PCF Retreat concentrated on key areas of research, including: (i) the biology of cancer stem cells and prostate cancer lineage plasticity; (ii) mechanisms of treatment resistance; (iii) emerging AI applications in diagnostic medicine; (iv) analytical and computational biology approaches in cancer research; (v) the role of nerves in prostate cancer; (vi) the biology of prostate cancer bone metastases; (vii) the contribution of ancestry and genomics to prostate cancer disparities; (viii) prostate cancer 3D genomics; (ix) progress in new targets and treatments for prostate cancer; (x) the biology and translational applications of tumor extracellular vesicles; (xi) updates from PCF TACTICAL Award teams; (xii) novel platforms for small molecule molecular glues and binding inhibitors; and (xiii) diversity, equity and inclusion strategies for advancing cancer care equity.ConclusionsThis meeting report summarizes the presentations and discussions from the 2023 PCF Scientific Retreat. We hope that sharing this information will deepen our understanding of current and emerging research and drive future advancements in prostate cancer patient care.

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MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans

Cited by 4 publications

References 56 publications

Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Updated Biomarkers for TNBC in African vs. Caucasian American Women

The 30th Annual Prostate Cancer Foundation Scientific Retreat Report

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