Climate change is one of the most pressing challenges of our time, with far-reaching impacts on global agriculture. As weather patterns become increasingly unpredictable and extreme events such as droughts, floods, and heat waves become more frequent, the need for climate-resilient crop varieties has never been more urgent. This review article provides a comprehensive exploration of the strategies and genetic adaptations employed in plant breeding to develop crop varieties capable of withstanding the challenges posed by a changing climate. The article commences by elucidating the critical role that climate change plays in agriculture, affecting factors such as temperature, precipitation and the prevalence of pests and diseases. It underscores the necessity of climate-resilient crop varieties to secure global food production and mitigate potential food crises. A fundamental pillar of climate resilience in agriculture is genetic diversity. The article highlights the significance of maintaining and utilizing diverse plant germplasm to breed new crop varieties that can adapt to a range of environmental stressors. It also examines the importance of conserving wild relatives of cultivated crops, as they often harbor valuable traits for climate adaptation. To develop climate-resilient crop varieties, plant breeding has evolved significantly over the years. The article explores various breeding approaches, starting with traditional methods such as selecting resilient varieties through conventional breeding. It delves into the development of crops that can withstand specific stressors like drought, heat, cold, and resist diseases and pests. The integration of modern genetic techniques is a game-changer, allowing breeders to make significant strides in developing climate-resilient crops.