Microsatellite DNA variants among the FVB/NJ, C58/J, and I/LnJ mouse strains

The mouse is a prime organism of choice for modelling human disease. Over 450 inbred strains of mice have been described, providing a wealth of different genotypes and phenotypes for genetic and other studies. As new strains are generated and others become extinct, it is useful to review periodically what strains are available and how they are related to each other, particularly in the light of available DNA polymorphism data from microsatellite and other markers. We describe the origins and relationships of inbred mouse strains, 90 years after the generation of the first inbred strain. Given the large collection of inbred strains available, and that published information on these strains is incomplete, we propose that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently.

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Genealogies of mouse inbred strains

Beck

et al. 2000

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Genetic evaluation of F2 inbred strain of Swiss albino mice by microsatellite markers

Kaushal

Kumar

et al. 2021

Indian J of Anim Sci

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Genetic characterization of F2 inbred Swiss albino mice was done using 11 microsatellites markers (D1Mit15, D2Mit51, D2Mit61, D3Mit15, D3Mit55, D5Mit18, D7Mit323, D8Mit14, D9Mit27, D10Mit180, and D11Mit167). The results indicated that genotypic frequencies at all the loci were in Hardy-Weinberg disequilibrium (P<0.001). Total number of alleles per locus ranged from 3 (D2Mit61, D3Mit15, D8Mit14, D9Mit27, D10Mit180, D11Mit167) to 4 (D1Mit15, D2Mit51, D3Mit55, D5Mit18, D7Mit323), with a mean of 3.45. The numbers of effective alleles ranged between 1.847 and 3.814. The observed heterozygosity (Ho) was maximum for D1Mit15 (0.660) and minimum for D5Mit18 (0.080), with mean of 0.269. The FIS estimates was ranged from 0.0817 (D1Mit15) to 0.8799 (D5Mit18). The average inbreeding coefficient was 0.592, which indicates that parents were more related than expected under random mating. The range of PIC value (from 0.414 to 0.689) for various microsatellite loci was revealing that population under investigation was of high diversity maintaining a multiple allele.

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Microsatellite DNA variants among the FVB/NJ, C58/J, and I/LnJ mouse strains

Cited by 2 publications

References 3 publications

Genealogies of mouse inbred strains

Genealogies of mouse inbred strains

Genetic evaluation of F2 inbred strain of Swiss albino mice by microsatellite markers

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