Microsatellite instability and oncological outcomes in Thai patients with endometrial cancer

Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease

“…Efforts have been made to reveal markers that may help identify high-risk, low-stage patients. Previous reports have linked both histological features, like MELF (Microcystic, elongated and fragmented) myoinvasion pattern 6 , 7 , 8 , 9 and genetic alterations, including microsatellite-instability 9 , 10 , 11 , 12 and CTNNB1 exon 3 hotspot mutation to worse prognosis for low-stage tumors, 13 however no marker has been identified that robustly predicts risk of recurrence in low-stage tumors. We postulate that the cellular composition of the tumor may affect its ability to spread.…”

Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers

“…Additionally, type 1 ECs are often known to be associated with some unique molecular alterations, also termed microsatellite instability (MSI), which is the result of the defects in DNA mismatch repair proteins. This is due to the accumulation of mutation loads in cancer-related genes and the generation of neoantigens, which stimulate the anti-tumor immune response of the host [206][207][208][209]. Moreover, F. nucleatum infection has also been linked to MSI in CRC and head and neck cancer patients due to impaired DNA mismatch repair (MMR) pathways [210][211][212].…”