2005
DOI: 10.1186/1471-2490-5-2
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Microsatellite instability as prognostic marker in bladder tumors: a clinical significance

Abstract: Background: Carcinoma of urinary bladder is one of the leading causes of death in India. Successful treatment of bladder cancer depends on the early detection & specific diagnostic approaches. In the present study, microsatellite instability (MSI) has been evaluated as a prognostic marker in patients with superficial urinary bladder cancer in lower urinary tract for determining risk of recurrence.

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Cited by 42 publications
(19 citation statements)
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“…Patients with MSI colorectal cancer showed a better prognosis than those with microsatellite stable cancer (36,37). However, the relationship of MSI to prognosis is still in dispute in bladder cancer (8,13,14). In superficial bladder cancers, as well as in colon cancers, the decrease in MMR protein expression was associated with a lower recurrence rate (8).…”
Section: Discussionmentioning
confidence: 99%
“…Patients with MSI colorectal cancer showed a better prognosis than those with microsatellite stable cancer (36,37). However, the relationship of MSI to prognosis is still in dispute in bladder cancer (8,13,14). In superficial bladder cancers, as well as in colon cancers, the decrease in MMR protein expression was associated with a lower recurrence rate (8).…”
Section: Discussionmentioning
confidence: 99%
“…These errors appear as gains or losses of gene loci and can be detected by examining the size of microsatellite repeat fragments, as the numbers of repeats in some of the microsatellites can change because of defective DNA repair [45]. Microsatellite instability has been evaluated as a prognostic marker and shown to be associated with tumor stage and grade [46].…”
Section: Structural Chromosomal Alterationsmentioning
confidence: 99%
“…Microsatellite profiles of bladder UCC have shown infrequent instability [9][10][11], which can be an independent prognostic marker for assessing risk of recurrence in superficial tumors irrespective of the grade [43]. Likewise, reduced expression of the MMR proteins may have an important contribution in the development of a subset of UCC and is a potentially useful prognostic marker [12,13], in particular for upper urinary tract tumors [44].…”
Section: Discussionmentioning
confidence: 98%