Microsatellite Instability in Hepatocellular Carcinomas From Two Different Geographic Regions (Portugal and Mozambique)

A Glance at Aflatoxin Research in Mozambique

“…However, Unsal, et al [ 28 ] demonstrated that HBV also has an important role in the wild-type p53 function, and this mutation seems rare outside Mozambique, even in other places with a high incidence of HCC and aflatoxin contaminated food. Sarmento, et al [ 29 ] carried out a pertinent following in this line of research, analyzing microsatellite instability in HCC among Portuguese and Mozambican subjects. However, their focus was only cancer, not exploring in depth the relationship between it and aflatoxins, HBV, or any other possible causes.…”

“…For example, Krishnappa, et al [ 51 ] tested the effect of garlic extract in the liver of Winstar rats damaged by aflatoxin B 1 and their results were satisfactory. Yet, this line of research is not likely to become a priority in Mozambique, though some key studies in the area were conducted in the country or based on the Mozambican population [ 1 , 25 , 27 , 29 ]. Among the reasons, the following can be considered: there is already some information on the matter in the country and much more locally known, though not available in the mainstream international literature.…”