Microsatellite Marker Content Mapping of 12 Candidate Genes for Obesity: Assembly of Seven Obesity Screening Panels for Automated Genotyping

Abstract

Twin studies, adoption studies, and studies of familial aggregation indicate that obesity has a genetic component. Whereas, the genetic factors predisposing to obesity have been elucidated for several rare syndromes, the factors responsible for obesity in the general population have remained elusive. Genetic studies of complex traits are often accelerated by the use of candidate genes. To facilitate genetic studies of human obesity, seven multiplex panels of candidate genes for obesity that are suitable for fluorescent genotyping have been assembled. The multiplex panels are composed of 66 microsatellite markers linked tightly to 16 human gene products that are of potential importance in the control of body weight or linked to syndromic forms of obesity. As part of these efforts 12 previously cloned genes have been placed on the human physical map. In addition the chromosomal location of three of these genes, ART,NYP Y6R, and PPARγ, are reported for the first time. These resources will be of use in studies to identify the genetic factors responsible for human obesity. [Figures are available at http://www.genome.org.]

Pharmacological Treatment of Obesity: Therapeutic Strategies

“…Weight gain can be a function of defective energy output as well as excessive caloric intake, and each of the 24 human chromosomes except the Y chromosome appears to contain obesity-related genes . To facilitate genetic studies of obesity, several multiplex panels of candidate genes for obesity that are suitable for fluorescent genotyping have been assembled . These mutliplex panels are composed of microsatellite markers linked tightly to 16 human gene products that are of potential importance in the control of body weight, including agouti-related transcript, neuropeptide Y (NPY) and its receptors (Y5 and Y6), proopiomelanocortin (POMC), uncoupling protein-2 (UCP-2), leptin and its receptor, and peroxisome proliferator-activated receptor (PPARγ).…”

QTL alleles on chromosome 7 from fatty Meishan pigs reduce fat deposition

“…Obesity is highly prevalent in Western society, affecting approximately one-third of the United States population and 20% of Europeans. In human, it has been proved to be exceedingly difficult to dissect polygenic disease traits [28] . Therefore comparative mapping of pig chromosome 7 could be interesting in search for candidate genes for human obesity.…”

“…The Wild Boar × Pietrain pedigree (W × P) comprised one male European Wild boar and nine female Pietrain founders, two F 1 males and 28 …”

SNP Detection of Carboxypeptidase E Gene and Its Association with Meat Quality and Carcass Traits in Korean Cattle

“…A single point mutation in the CPE gene was identified as the cause of obesity in the fat/fat mouse (Naggert et al, 1995). The fat gene encodes CPE, a candidate gene as markers in genetic studies of human obesity (Winick and Friedman, 1998). Therefore, based on the role of CPE in obesity, the gene encoding CPE was chosen as a candidate gene for association tests with meat traits and quality in beef cattle.…”