Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral diseases

Larruskain, Amaia; Minguijón, E.; Aróstegui, Inmaculada; Moreno, Bernardino; Juste, Ramón A.; Jugo, Begoña M.

doi:10.1016/j.vetimm.2011.12.020

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…In addition, Class I and II polymorphic gene variants have been linked to SRLV provirus levels and disease progression (See Table 2 for more details; [64,95,96]).…”

Section: Host Genetic Factors Involved In Srlv-induced Pathogenesismentioning

confidence: 99%

Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction

Larruskain

Jugo

2013

Viruses

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Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. Both infect cells of the monocyte/macrophage lineage and cause lifelong infections. Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. VM and CAE are distributed worldwide and develop over a period of months or years, always leading to the death of the host, with the consequent economic and welfare implications. Currently, the control of VM and CAE relies on the control of transmission and culling of infected animals. However, there is evidence that host genetics play an important role in determining Susceptibility/Resistance to SRLV infection and disease progression, but little work has been performed in small ruminants. More research is necessary to understand the host-SRLV interaction.

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“…In addition, Class I and II polymorphic gene variants have been linked to SRLV provirus levels and disease progression (See Table 2 for more details; [64,95,96]).…”

Section: Host Genetic Factors Involved In Srlv-induced Pathogenesismentioning

confidence: 99%

Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction

Larruskain

Jugo

2013

Viruses

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“…Such measurements have the advantage of reflecting viral replication. Another measure of control is scoring to reflect the severity of pathological tissue lesions in infected animals [83,84,85]. Such measurements can reflect not only viral activity but also immunopathogenesis, in which immune responses from the host that can cause collateral damage in or near infected cells.…”

Section: Development Of Genetic Marker Tests For Small Ruminant Lementioning

confidence: 99%

“…In addition to building understanding of infection and disease, such valuable results prepare the way for further work to address whether such genetic variants exist in small ruminants, and if so, begin developing genetic marker tests. Other helpful literature includes individual association studies performed on various sheep genes and gene regions in connection with OvLV traits, such as DRB1 , CCR5 , TLR7 , TLR8 , TLR9 , and additional MHC loci [34,74,76,78,84,85], and the many reports of significant association at several genetic loci would pass the first evidence-based stage outlined in Table 1. These, too, are promising research results that advance understanding of host-pathogen interaction, and they advance the field in important ways.…”

Section: Development Of Genetic Marker Tests For Small Ruminant Lementioning

confidence: 99%

“…Many initial genetic associations have been reported with differential odds of infection and/or control (Table 4) [34,74,77,84,85]. These include high quality work on MHC gene and MHC region associations, including susceptibility alleles potentially similar to those used successfully in marker-assisted selection for other infectious disease traits [205].…”

Section: Future Opportunities and Needsmentioning

confidence: 99%

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Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding

White

Knowles

2013

Viruses

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Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic component in susceptibility to infection by OvLV in sheep. A genetic marker test for susceptibility to OvLV has been developed recently based on the TMEM154 gene with validation data from over 2,800 sheep representing nine cohorts. While no single genotype has been shown to have complete resistance to OvLV, consistent association in thousands of sheep from multiple breeds and management conditions highlight a new strategy for intervention by selective breeding. This genetic marker-assisted selection (MAS) has the potential to be a useful addition to existing viral control measures. Further, the discovery of multiple additional genomic regions associated with susceptibility to or control of OvLV suggests that additional genetic marker tests may be developed to extend the reach of MAS in the future. This review will cover the strengths and limitations of existing data from host genetics as an intervention and outline additional questions for future genetic research in sheep, goats, small ruminant lentiviruses, and their host-pathogen interactions.

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“…Our previous work analysed the involvement of major histocompatibility complex class I and II loci in OPA and identified several alleles associated with the presence of OPA lesions (Larruskain et al 2010(Larruskain et al , 2012a. This SNPbased work extends the analysis of ovine immunity genes that could influence the pathogenesis of OPA, analysing cytokines, a chemokine receptor, Toll-like receptors (TLRs) and three other innate immunity genes with antiviral activity.…”

Section: Introductionmentioning

confidence: 80%

SNPs in candidate genes MX dynamin‐like GTPase and chemokine (C‐C motif) receptor‐5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep

et al. 2015

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Ovine pulmonary adenocarcinoma (OPA) is a contagious lung cancer in sheep caused by Jaagsiekte sheep retrovirus (JSRV). OPA is present in many sheep-rearing countries causing economic and welfare issues, as currently no efficient vaccines or treatments are available. Breed differences suggest a host genetic component may influence the pathogenesis of OPA, but so far few genes have been identified. In this work, a genetic association study was carried out in Latxa dairy sheep which were classified as cases/controls based on the presence/absence of OPA lung tumours. Candidate genes included cytokines and a receptor and innate immunity genes. After SNPs in the candidate genes were identified, the distribution of alleles in cases and controls was compared by means of logistic regression analyses at the allelic, genotypic and haplotypic levels. The association analysis showed that several candidate genes were significantly associated with resistance or susceptibility to OPA; two of the candidates, CCR5 and MX1, remained significantly associated with resistance and susceptibility respectively, even after Bonferroni correction.

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Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral diseases

Cited by 9 publications

References 35 publications

Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction

Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction

Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding

SNPs in candidate genes MX dynamin‐like GTPase and chemokine (C‐C motif) receptor‐5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep

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