The Eastern South China Block (SCB) has experienced complex Mesozoic‐Cenozoic tectonism and intraplate volcanism. However, due to a lack of exhaustive exploration of the upper mantle's thermochemical structure, it is difficult to determine the extent of the lithospheric modification and the mechanisms by which the volcanism generate. Here, we jointly invert Rayleigh wave dispersion, surface heat flow, geoid height, and elevation data to provide a comprehensive thermal and compositional structure of the upper mantle beneath eastern SCB and infer regions of partial melting. Our model reveals widespread lithospheric thinning in the eastern SCB and large variations of lithospheric composition with a more fertile eastern Lower Yangtze lithosphere than the lithosphere elsewhere, suggesting the lithosphere of the eastern Lower Yangtze is more severely modified than the rest of the SCB. Moreover, two high‐temperature anomalies are revealed: one beneath the eastern Lower Yangtze and the other beneath the Pearl River Delta region, associated with the Pacific plate subduction and Hainan plume, respectively. The high‐degree partial melting (∼6%) in the asthenosphere beneath the Lower Yangtze is responsible for the strong ongoing lithospheric modification and the young intraplate volcanism in the Nvshan and Subei areas. Small‐scale upper mantle convections triggered by the large mantle upwellings created a low value of ∼3% melts, possibly responsible for the intraplate volcanism in the coastal CB and less severe lithospheric modification. We demonstrate that the lithospheric thickness and its thermochemical state are the key factors that influence the composition and evolution of intraplate volcanism in the eastern SCB.