Microscale Inorganic LED Based Wireless Neural Systems for Chronic in vivo Optogenetics

Qazi, Raza; Kim, Choong Yeon; Byun, Sanghyuk; Jeong, Jae‐Woong

doi:10.3389/fnins.2018.00764

Cited by 31 publications

(30 citation statements)

References 20 publications

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“…2. In all scenarios, a critical objective is to design a fully implantable, miniaturize, flexible, biointegrated, and wireless platforms [15], [17], [18], [37]- [40]. Use of biocompatible material plays an important role both chemically and mechanically, and prerequisite to permit a durable, least invasive operation of the brain [41].…”

Section: Neural Device Interfacesmentioning

confidence: 99%

“…Along with the critical importance of the biocompatibility, mechanical flexibility as well as conformality to the desired tissues forms the foundation of a long-term biointegration [42]. Furthermore, wireless power transfer (WPT) to the neural implant ensures tether-free, highly mobile social connections or recordings in naturalistic situations for the tested animals [15], [17], [18]. In summary, reducing the size and weight is an inevitable engineering prospect [5].…”

Section: Neural Device Interfacesmentioning

confidence: 99%

“…Implantable neural devices based on tethered and rigid devices initiate considerable tissue damage and disturbance with the normal behaviour of animals, thereby hampering chronic in vivo operations [15]- [18]. The mechanical mismatch and micromotion introduced by the interconnection that links the neural implant placed near the brain and skull-mounted connector (i.e., tether), can be minimized by using a wireless power system.…”

mentioning

confidence: 99%

“…The mechanical mismatch and micromotion introduced by the interconnection that links the neural implant placed near the brain and skull-mounted connector (i.e., tether), can be minimized by using a wireless power system. The most commonly used wireless power technologies used are electromagnetic, photovoltaic, and ultrasound [15], [18]. The ultrasound-based power transfer method uses ultrasound to vibrate an energy harvester based on implantable piezoelectric.…”

mentioning

confidence: 99%

“…As a result, the electromagnetic based wireless power transfer, which working principle is the electromagnetic induction, This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see http://creativecommons.org/licenses/by/4.0/ still the most popular choice to realize the fully implantable, wirelessly powered, and miniaturized neural devices for chronic implantation [15], [16], [18].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Das

Moradi

Heidari

2020

IEEE Trans. Biomed. Circuits Syst.

126

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Implantable neural interfacing devices have added significantly to neural engineering by introducing the lowfrequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.Index Terms-Biocompatibility, biointegration, implantable neural device, mechanical flexibility, wireless power transfer.

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Section: Neural Device Interfacesmentioning

confidence: 99%

Section: Neural Device Interfacesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Das

Moradi

Heidari

2020

IEEE Trans. Biomed. Circuits Syst.

126

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Rapidly Customizable, Scalable 3D‐Printed Wireless Optogenetic Probes for Versatile Applications in Neuroscience

Lee

Parker

Kawakami

et al. 2020

Adv Funct Materials

Self Cite

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Optogenetics is an advanced neuroscience technique that enables the dissection of neural circuitry with high spatiotemporal precision. Recent advances in materials and microfabrication techniques have enabled minimally invasive and biocompatible optical neural probes, thereby facilitating in vivo optogenetic research. However, conventional fabrication techniques rely on cleanroom facilities, which are not easily accessible and are expensive to use, making the overall manufacturing process inconvenient and costly. Moreover, the inherent time-consuming nature of current fabrication procedures impede the rapid customization of neural probes in between in vivo studies. Here, a new technique stemming from 3D printing technology for the low-cost, mass production of rapidly customizable optogenetic neural probes is introduced. The 3D printing production process, on-the-fly design versatility, and biocompatibility of 3D printed optogenetic probes as well as their functional capabilities for wireless in vivo optogenetics is detailed. Successful in vivo studies with 3D printed devices highlight the reliability of this easily accessible and flexible manufacturing approach that, with advances in printing technology, can foreshadow its widespread applications in low-cost bioelectronics in the future.

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Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

2019

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of Things (IoT) to wellness and medical technologies. In the past decade, significant efforts have been deployed to exploit these technologies to design and manufacture conformable bioelectronic interfaces.Mechanical compliance is a critical specification for the long-term integration of on-skin devices and implants with a biological host. The latter is largely composed of soft tissues, with Young's moduli E in the range from 100 Pa to 10 MPa (excluding bones and cartilage), [1] and sustains different physiological dynamic behaviors, e.g., repeated displacements of hundreds of micrometers at 1 Hz in the heart or brain, [2] volumetric changes up to 8% in the heart, [3] or large flexion and angular displacement in the skin or spinal cord. [4] In contrast, electronic materials are stiff, with the elastic modulus in the range of 1 GPa (organic materials) to 100 GPa (inorganic materials) and rigid, bearing little strain without displaying mechanical failure or defect generation. Interfaces between such disparate biological and man-made materials suffer therefore from a mechanical mismatch that hinders reliable and continued device function in the body. [1,5] Several approaches have been used to engineer mechanical compliance within an electronic device or circuit. [6] Outcomes of such conformable circuits include improved mitigation of foreign body reaction (FBR) in vivo compared to rigid interfaces, [7] access to so far unreachable regions, [8] and bidirectional communication with high spatiotemporal resolution with the biological host.Monolithic integration of electronic devices and circuits on semiconductor wafers offers extreme miniaturization and very high device density (e.g., >10 8 transistors mm −2 , Intel FinFET Technology nodes [9] ). Such large scale of integration cannot be achieved for electronics prepared on conformable carrier substrates, as this class of devices employs lower performance device materials and polymeric substrates with low chemical and/or thermal stability leading to limited lithographic resolution and large transistor sizes. These constraints typically worsen as the compliance of the substrate increases. Some of the highest device densities reported to date are >10 000 cm −2 on flexible substrate [10] and 347 cm −2 on stretchable carrier. [11] Conformable hybrid systems leverage the performance of standard complementary metal-oxide-semiconductor integrated circuits (ICs) and the compliance of discrete flexible or stretchable components and carriers, to effectively provide high-performance and mechanically compliant electronic circuits. They call for new Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and paralysis. Combining reduced invasiveness with advanced electronic functions, hybrid bioelectronic systems have evolved tremendously in the last decade, pushed by progress in materials ...

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Microscale Inorganic LED Based Wireless Neural Systems for Chronic in vivo Optogenetics

Cited by 31 publications

References 20 publications

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Rapidly Customizable, Scalable 3D‐Printed Wireless Optogenetic Probes for Versatile Applications in Neuroscience

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

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