Microscopic biopsy after unsuccessful endoscopic biopsy for primary central nervous system lymphoma of the corpus callosum: A case report

Abstract

Introduction and importance Primary central nervous system lymphoma (PCNSL) is a rare tumor with a poor prognosis. Early brain biopsy is essential to avoid a diagnostic delay. To date, reports of successful diagnosis for PCNSL of the corpus callosum by endoscopic biopsy are rare. Case presentation Herein, we report the case of an elderly woman with PCNSL of the corpus callosum who initially presented with rapidly progressive dementia. The condition was finally diagnosed by microscopic biopsy after unsuccessful endoscopic biopsy. Moreover, the postoperative course was uneventful. She is currently receiving systemic chemotherapy. Clinical discussion Early diagnosis and subsequent systemic chemotherapy with or without whole brain radiotherapy are critical for PCNSL. Endoscopic biopsy may be a diagnostic option for suspected PCNSL, although stereotactic needle biopsy is most commonly used. Conclusion Utilizing neuronavigation and 5-aminolevulinic acid (ALA) fluorescence guidance could be helpful in identifying lesions insufficiently exposed by endoscopic visualization. However, cerebrospinal fluid (CSF) loss due to the endoscopic approach through the ventricle might be a cause of neuronavigation misregistration.

Research on the Damage of the Central Nervous System Lymphoma to the Nervous System

“…A 63-year-old man with PCNSL masses in the frontal and parietal cortex who was admitted for left hemiplegia following a seizure [71] . Another elderly woman with progressive dementia had PCNSL manifest in the corpus callosum [72] . A patient who suffered multifocal, extensive lesions in the cerebral hemispheres and the corpus callosum presented with severe numbness throughout her left face, arm, and leg [73] .…”