Microscopic colitis as a missed cause of chronic diarrhea

Mohamed, Nooroudien

doi:10.3748/wjg.v17.i15.1996

Cited by 17 publications

(19 citation statements)

References 31 publications

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“…Wang et al mentioned 12 patients fulfilled the histological criteria but not the clinical criteria for classic LC and classified them as having atypical LC [19]. Nooroudien et al retrospectively reviewed non-malignant colon mucosal biopsies with 20 cases of LC, and mentioned the most common presenting complaints of them were chronic diarrhea in 9/20 cases, abdominal pain in 7/20 and constipation in 3/20 [1]. Neal et al studied clinicopathological association and prevalence of LC in 100 asymptomatic, non-gluten sensitive adults who underwent screening surveillance colonoscopy for previous colonic polyps as a control group without a clinical symptom, and none had abdominal pain, weight loss or altered bowel habits.…”

Section: Discussionmentioning

confidence: 99%

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Lansoprazole Associated Lymphocytic Colitis With Irritable Bowel Syndrome in a Patient Without Symptoms of Diarrhea

Pişkinpaşa¹,

Pişkinpaşa²,

Sertbaş³

2015

J Med Cases

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We present a case of 64-year-old woman patient who developed microscopic colitis undergoing lansoprazole therapy for gastroesophageal reflux disease. Abdominal pain and mild weight loss had been developed. She had no symptoms of diarrhea. Appearance on colonoscopy was normal, but biopsies showed lymphocytic colitis. Lansoprazole therapy was ceased. A repeat colonoscopy 2 months after discontinuation revealed endoscopic and histological normalization.

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Section: Discussionmentioning

confidence: 99%

“…There are well-defined histological findings and normal or nearly normal macroscopic findings on colonoscopy [1]. Collagenous colitis (CC) and lymphocytic colitis (LC) are the two major histological forms of MC.…”

Section: Introductionmentioning

confidence: 99%

Lansoprazole Associated Lymphocytic Colitis With Irritable Bowel Syndrome in a Patient Without Symptoms of Diarrhea

Pişkinpaşa¹,

Pişkinpaşa²,

Sertbaş³

2015

J Med Cases

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“…As IBS, like other functional GI diseases, is rarely life-threatening, medical consultation rates amongst sufferers are known to be low. CD3 staining for lymphocytes was not carried out which may have resulted in an under-diagnosis of lymphocytic colitis [37]. Screening for Coeliac Disease, rare among our population but known to be associated with collagenous colitis, was not performed.…”

Section: Discussionmentioning

confidence: 99%

Low prevalence of ‘classical’ microscopic colitis but evidence of microscopic inflammation in Asian Irritable Bowel Syndrome patients with diarrhoea

et al. 2013

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BackgroundThere is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine the prevalence of microscopic colitis and inflammation in Malaysian IBS patients with diarrhoea (IBS-D).MethodsConsecutive patients who met the Rome III criteria for IBS-D and asymptomatic controls were prospectively recruited. Colonoscopy was performed in all study subjects and systematic biopsies taken from all segments of the colon. The diagnosis of lymphocytic colitis and collagenous colitis was made using previously defined criteria. Patients with post infectious IBS were excluded.Results120 subjects (74 IBS-D, 46 controls) were recruited during the study period. In the IBS-D group, the colonoscopic (macroscopic) findings were as follows; normal findings n = 58 (78.4%), diverticula disease n = 5 (6.8%), diminutive polyps n = 9 (12.2%) and haemorrhoids n = 2(2.7%). No subject under the age of 40 had any significant findings. Microscopically, there was only one case (1.3%) with histology consistent with collagenous colitis. However, the IBS-D patients had a higher prevalence of moderate microscopic inflammation (n = 11, 14.9%) compared to controls (n = 1, 2.2%) (p = 0.005).Conclusions‘Classical’ microscopic colitis is uncommon in Malaysian patients with IBS-D but a significant number of adults showed evidence of microscopic inflammation.

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“…Even if CC is more prevalent in women of about fifty, there is no female predominance [2]. The CC may precede, occur concomitantly or follow-up the disease joint [3].…”

Section: Discussionmentioning

confidence: 99%

Collagenous Colitis and Spondylarthropathy

Abdelghani

Sahli

Souabni

et al. 2012

Case Reports in Medicine

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Collagenous colitis is a recent cause of chronic diarrhea. Cooccurrence with spondylarthropathy is rare. We describe two cases: one man and one woman of 33 and 20 years old were suffering from spondylarthropathy. They then developed collagenous colitis, 4 and 14 years after the onset of spondylarthropathy. The diagnosis was based on histological features. A sicca syndrome and vitiligo were observed with the female case. The presence of colitis leads to therapeutic problems. This association suggests a systemic kind of rheumatic disease of collagenous colitis.

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Microscopic colitis as a missed cause of chronic diarrhea

Abstract: Immunohistochemistry using CD3 is of value in identifying and quantifying IELs for the presence of microscopic colitis in patients with diarrhea-predominant IBS.

Cited by 17 publications

References 31 publications

Lansoprazole Associated Lymphocytic Colitis With Irritable Bowel Syndrome in a Patient Without Symptoms of Diarrhea

Lansoprazole Associated Lymphocytic Colitis With Irritable Bowel Syndrome in a Patient Without Symptoms of Diarrhea

Low prevalence of ‘classical’ microscopic colitis but evidence of microscopic inflammation in Asian Irritable Bowel Syndrome patients with diarrhoea

Collagenous Colitis and Spondylarthropathy

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