“…Epidemiological studies have shown that the actual incidence and prevalence of MC are higher than initially thought and still show a rising incidence, although this rise is far less pronounced than in the past [9]. A populationbased cohort study conducted from 1985 to 2001 in Olmsted County, Minnesota, showed that the incidence of CC was 3.1 per 100,000 and that of LC was 5.5 per 100,000 [5,10].…”