Microscopic diversity in oral Kaposi sarcoma

Bunn, Belinda Kathleen; Carvalho, Marianne de Vasconcelos; Louw, Melanie; Vargas, Pablo Agustı́n; Heerden, W.F.P. Van

doi:10.1016/j.oooo.2012.11.009

Cited by 18 publications

(13 citation statements)

References 30 publications

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“…A wide spectrum of clinical and histopathological morphologies of KS poses a difficulty in differential diagnosis and a delay in the diagnosis and treatment of the disease [15, 16]. In certain areas of our country classical-type KS is a commonly encountered cutaneous vascular neoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few studies studying histological subtypes of KS in large samples [2–6, 16, 17]. In this study 185 classical-type cutaneous KS lesions from 79 patients were retrospectively assessed, and two cases showing cavernous hemangioma-like features were reported with regard to histopathological features and differential diagnosis in company with the literature data.…”

Section: Discussionmentioning

confidence: 99%

“…Differential diagnosis of CHLKS includes many reactive and benign vascular lesions [1, 15, 16]. In addition, dilated vascular structures resembling cavernous hemangioma may also be seen around the spindle cell proliferation in some lesions at the nodular stage of the usual type of KS (see Figure 1).…”

Section: Discussionmentioning

confidence: 99%

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Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis

Kandemır

Barut

Gün

et al. 2013

Case Reports in Medicine

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Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis

Kandemır

Barut

Gün

et al. 2013

Case Reports in Medicine

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“…Histopathological diagnosis of early stage KS depends on the detection of subtle clues that can be easily missed by the pathologist [56]. Well-established clinical lesions of KS however typically, but not always, display characteristic histopathological features that can be accurately diagnosed by a trained histopathologist [57–60]. …”

Section: Diagnosis and Pathologymentioning

confidence: 99%

Diagnosis and Treatment of Kaposi Sarcoma

2017

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Kaposi Sarcoma (KS) is the most common neoplasm of people living with HIV today. In Sub-Saharan Africa KS is among the most common cancers in men, overall. Not only HIV+ individuals present with KS; any immune compromised person infected with Kaposi Sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 is at risk: the elderly, children in KSHV-endemic areas, and transplant recipients. KS diagnosis is based on detection of the viral protein LANA in the biopsy, but not all cases of KS are the same or will respond to the same therapy. Standard KS therapy has not changed in 20 years, but newer modalities are on the horizon and will be discussed.

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“…El sarcoma de Kaposi (SK) es una neoplasia vascular de malignidad intermedia que afecta la piel, mucosa, ganglios linfáticos y vísceras (más frecuente en estómago y pulmón) (1). Actualmente es la neoplasia más frecuentemente asociada al SIDA a pesar de que la terapia antirretroviral de gran actividad (HAART) ha significado un gran cambio en la evolución natural de la infección por el virus de inmunodeficiencia humana (VIH) con disminución de la incidencia de sarcoma de Kaposi en pacientes VIH (3).…”

Section: Introductionunclassified

Sarcoma de Kaposi lingual. Rara variante en paciente VIH positivo. A propósito de un caso.

Santamarı́a¹,

Mengual²,

Nodar³

2020

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Kaposi's sarcoma is a vascular lesion of intermediate-grade malignant potential affecting skin, mucosa, lymph nodes, and viscera. Four clinical variants have been recognized: classic, African Kaposi sarcoma, immunosuppression-associated Kaposi sarcoma and AIDS-associated Kaposi sarcoma. Human herpes virus type 8 is implicated as the etiological agent in all of them. We present a 39-year-old man with a history of pulmonary tuberculosis under treatment, and two months of evolution HIV / AIDS, with a lympangiomatous Kaposi sarcoma in an atypical location. Keywords: Kaposi's sarcoma; HIV; HHV-8; vascular neoplasia; lymphangioma-like Kaposi sarcoma.

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Microscopic diversity in oral Kaposi sarcoma

Abstract: Kaposi sarcoma is the most common HIV-associated neoplasm, frequently presenting with oral mucosal involvement. This retrospective study aimed to assess

Cited by 18 publications

References 30 publications

Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis

Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis

Diagnosis and Treatment of Kaposi Sarcoma

Sarcoma de Kaposi lingual. Rara variante en paciente VIH positivo. A propósito de un caso.

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