Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of process variables

A multivariate approach applied to quality on particle engineering of spray-dried mannitol

“…The SDM shape was characterized using the circularity, u, as defined in Eq. (2). The values of u for all conditions of SDM preparation are presented in Table 2, as well as the results of ANOVA analysis on the data.…”

“…Recent pharmaceutical applications of spray drying are related to the modifications on particle size, surface and shape with the aim of improving drug carrier in what concern drug delivery to the lungs. These morphological characteristics directly affects physical and chemical properties of pharmaceutical powders and have attracted attention recently, mainly because the advances in computing and image technologies [2,3]. Vehring [4] reviewed the recent development in particle engineering field and provides concepts and theoretical framework for particle design calculations.…”

Supremacy of modern morphometry in typing renal oncocytoma and malignant look-alikes

“…Although JPEG compression alters characteristics of pixels in an image, including shape and size, this format is used as a standard format for image analysis and digital microscopy. Several studies have demonstrated that JPEG compression does not negatively affect the quality of images and the accuracy of diagnosis (Marcelo et al 2000;Almeida-Prieto et al 2006;Hedvat 2010).…”

Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance

“…In all cases the images were captured with an Olympus BX60 microscope connected to a DP11 camera in jpg format at a resolution of pixel size of 4.26 microns and binary images were obtained from digitized images using a relative greylevel threshold of 60% (Almeida-Prieto et al, 2006).…”