Microscopic markers of an infradian biorhythm in human juvenile ribs

Pitfield, Rosie; Miszkiewicz, Justyna J.; Mahoney, Patrick

doi:10.1016/j.bone.2018.11.019

Cited by 5 publications

(2 citation statements)

References 65 publications

(93 reference statements)

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“…Our previous studies suggest aspects of human growth may relate to RP-biorhythm. Specifically, we have shown that the size of microscopic canals that house blood vessels in human adolescent ribs relates to RP 49 . Larger canals facilitate greater blood flow and nutrient transfer 50 , 51 .…”

Section: Introductionmentioning

confidence: 95%

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Dental biorhythm is associated with adolescent weight gain

et al. 2022

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Background Evidence of a long-period biological rhythm present in mammalian hard tissue relates to species average body mass. Studies have just begun to investigate the role of this biorhythm in human physiology. Methods The biorhythm is calculated from naturally exfoliated primary molars for 61 adolescents. We determine if the timing relates to longitudinal measures of their weight, height, lower leg length and body mass collected over 14 months between September 2019 to October 2020. We use univariate and multivariate statistical analyses to isolate and identify relationships with the biorhythm. Results Participants with a faster biorhythm typically weigh less each month and gain significantly less weight and mass over 14-months, relative to those with a slower biorhythm. The biorhythm relates to sex differences in weight gain. Conclusions We identify a previously unknown factor that associates with the rapid change in body size that accompanies human adolescence. Our findings provide a basis from which to explore novel relationships between the biorhythm and weight-related health risks.

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Section: Introductionmentioning

confidence: 95%

“…Thus, in contrast to the interspecific positive correlation between the duration of growth periods and body size and RP, the idea is that stature and RP should correlate negatively in humans. Currently, however, evidence of the biorhythm in relation to human growth 49 , 52 is limited.…”

Section: Introductionmentioning

confidence: 99%

Dental biorhythm is associated with adolescent weight gain

et al. 2022

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Chronobiological Aspects of Spontaneous Ultra-Weak Photon Emission in Humans: Ultradian, Circadian and Infradian Rhythms

Scholkmann

2023

Ultra-Weak Photon Emission From Biological Systems

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Rib remodelling changes with body size in fossil hippopotamuses from Cyprus and Greece

Miszkiewicz,

Athanassiou,

Lyras

et al. 2023

J Mammal Evol

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Large species that are isolated for thousands of years on islands often evolve extreme degrees of dwarfism. Very little is known about physiological processes that accompany such extreme transitions in extinct dwarf species. We tested whether physiological cycles of bone maintenance (remodelling) in dwarf adult hippopotamuses correlate with insularity-driven body mass shifts that may occur due to variables such as ecological release from predation pressure and change in access to resources. We hypothesised that hippopotamuses with the smallest body size should show higher values of osteocyte lacunae, proxies for osteoblast proliferation during cycles of remodelling, when compared to relatively larger dwarf forms, as well as much larger mainland common hippopotamuses. We examined 20 ribs from three extinct Pleistocene Hippopotamus species spanning a gradient in body size: H. minor (~132 kg, Cyprus), H. creutzburgi (~398 kg, Crete), and H. antiquus (~3200 kg, mainland Greece). Ribs were selected because they reflect bone metabolic rates that are not completely clouded by factors such as biomechanics. Densities of osteocyte lacunae (Ot.Dn) were examined in 864 individual secondary osteons observed in histology sections. We found the highest average Ot.Dn in the H. minor ribs, intermediate Ot.Dn in the H. creutzburgi ribs, and the lowest Ot.Dn in the H. antiquus ribs. It appears that Ot.Dn distinctly separated these three species, possibly signifying a gradient in bone remodelling such that bone tissue optimises maintenance in the face of insularity-driven reduction of body size. We discuss hippopotamus rib bone microstructure and the utility of Ot.Dn in palaeontological analyses for elucidating intricate biological processes occurring in bone of insular fossil mammals.

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Microscopic markers of an infradian biorhythm in human juvenile ribs

Abstract: The version in the Kent Academic Repository may differ from the final published version. Users are advised to check http://kar.kent.ac.uk for the status of the paper. Users should always cite the published version of record.

Cited by 5 publications

References 65 publications

Dental biorhythm is associated with adolescent weight gain

Dental biorhythm is associated with adolescent weight gain

Chronobiological Aspects of Spontaneous Ultra-Weak Photon Emission in Humans: Ultradian, Circadian and Infradian Rhythms

Rib remodelling changes with body size in fossil hippopotamuses from Cyprus and Greece

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