The use of nano-Raman spectroscopy to study two-dimensional (2D) systems is presented here. The nano (tip-enhanced) Raman spectroscopy (TERS) technique is briefly introduced, addressing some new theoretical aspects for Raman spectroscopy in the near-field regime, including field coherence, field distribution and the relevance of atomic description and quenching effects. State-of-the-art results in graphene and transition metal dichalcogenides are presented, exploring the connection between micro- and nano-Raman metrology. Various aspects such as defects, homojunctions, twisted-bilayer structures, localized emissions at bubbles, wrinkles, and borders, as well as substrate and coherence effects are addressed in detail. The paper concludes by outlining the perspectives for nano-Raman spectroscopy in 2D systems, highlighting its potential for advancing our understanding of nanoscale phenomena and facilitating further breakthroughs in materials science and characterization.