Microscopic polyangiitis associated with antiphospholipid syndrome.

Handa, Rohini; Aggarwal, Prerana; Biswas, Abhishek; N, Wig; Wali, J P

doi:10.1093/rheumatology/38.5.478

Cited by 16 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isolated case reports and small case series have described positive aPL and/or a concurrent diagnosis of APS in a variety of vasculitides, including GPA, MPA, polyarteritis nodosa, giant cell arteritis, and Takayasu arteritis . Our results show that 34% of AAV patients (n = 40) in our study cohort had persistently positive aPL.…”

Section: Introductionsupporting

confidence: 52%

Association of Lupus Anticoagulant With Long‐Term Damage Accrual in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Jordan

D’Cruz

2016

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. Antiphospholipid antibodies (aPL) are frequently present in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients; however, the prognostic impact of aPL in such patients has not been elucidated. The objective of this study was to determine whether persistent aPL positivity in AAV patients was associated with increased long-term damage accrual. Methods. Clinical data were retrospectively collected on all AAV patients who attended the vasculitis clinic at our center over a 4-year period. Data collection included presence of lupus anticoagulant (LAC) and IgG and IgM anticardiolipin (aCL) antibody titers, along with concurrent diagnosis of antiphospholipid syndrome (APS). Accumulation of long-term damage was quantified using the Vasculitis Damage Index (VDI). Results. Data from 116 AAV patients were analyzed. A total of 34% (n 5 40) had persistently positive aCL or LAC or a concurrent diagnosis of APS and were classified as AAV/aPL. A total of 76 patients (66%) were classified as AAV alone. LAC was present in a statistically higher proportion of AAV/aPL patients than those in the AAV-alone group (P < 0.0001). Mean VDI score was significantly higher in the AAV/aPL group at mean 6 SD 3.54 6 1.36 as compared to 1.96 6 1.42 in the AAV-alone group (P < 0.0001). Major vascular damage scores were significantly higher in the AAV/ aPL group, with mean 6 SD 0.32 6 0.59 as compared to 0.07 6 0.26 in the AAV-alone group (P < 0.007). Conclusion. Persistently positive occurrence of aPL, in particular LAC, is present in a significant proportion of AAV patients and is associated with a higher VDI score. Clinicians should consider screening AAV patients for aPL.

show abstract

Section: Introductionsupporting

confidence: 52%

Association of Lupus Anticoagulant With Long‐Term Damage Accrual in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Jordan

D’Cruz

2016

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…Antiphospholipid antibodies (aPL) and thrombosis may also occur in patients with primary systemic vasculitis (PSV). Several case reports have described APS in individual patients with polyarteritis nodosa, 1-4 microscopic polyangiitis, 5 and, in particular, Wegener's granulomatosis. 6 Other reports describe several patients with giant cell arteritis/polymyalgia rheumatica and APS [7][8][9] or Behçet's disease and APS.…”

mentioning

confidence: 99%

Prevalence of the antiphospholipid syndrome in primary systemic vasculitis

Rees

2006

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Background: The antiphospholipid (APS or Hughes') syndrome, anticardiolipin antibodies (aCL), and the lupus anticoagulant (LA) are associated with systemic lupus erythematosus, malignancy, infection, and drugs. It has been described in patients with primary systemic vasculitis (PSV). Objective: To determine the prevalence of APS in patients with PSV attending a vasculitis clinic and the prevalence of patients with positive aCL and/or the LA who do not fulfil the classification criteria for APS. Methods: All case notes of patients attending the vasculitis clinic over a 12 month period were reviewed. Outpatients and inpatients were both included and were assessed for features of the APS and presence of aPL. Patients with positive aCL or LA tests were classified according to the significance of these results. Results: Of 144 patients with PSV, 25 had positive aCL or LA on at least one occasion, representing a point prevalence of 17%. Of these, nine had definite APS (classified by the Sapporo criteria) and a further four patients had clinical and serological features of APS, although insufficient to satisfy the Sapporo criteria. Twelve had only positive aPL. Conclusion: The antiphospholipid syndrome, aCL, and the LA may occur in association with PSV.

show abstract

“…40 There are scattered case reports of APS occurring in the context of all of the subtypes of AAV. 41,42 As in APS, patients with AAV can present with pulmonary capillaritis and DAH. There are 2 reports of pulmonary capillaritis occurring in GPA patients with concurrent APS and deep venous thrombosis.…”

Section: Small-vessel Vasculitismentioning

confidence: 99%