Microscopic Venous Infiltration As Predictor Of Relapse In Renal Cell Carcinoma

Mrstik, Christof; Salamon, Julius; Weber, Renate; Stögermayer, F.

doi:10.1016/s0022-5347(17)36569-2

Cited by 51 publications

(22 citation statements)

References 19 publications

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“…Although our definition of vascular invasion differs in detail from the definitions of others, the finding that it is a strong and independent prognostic indicator is broadly similar [5,11,12]. We have also shown that RVI and MVI have a similar prognostic effect.…”

Section: Discussionsupporting

confidence: 51%

Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma

Griffiths¹,

Verghese²,

Golash

et al. 2002

BJU International

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Section: Discussionsupporting

confidence: 51%

Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma

Griffiths¹,

Verghese²,

Golash

et al. 2002

BJU International

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“…In the studies by Mrstik et al [18] and Yildiz et al [13], when stratifying tumour extension (pT stage) and nuclear grading against MVI, the latter retained a greater influence on disease-free survival. In those studies the results suggested that the presence of MVI worsens the prognosis significantly, independent of other risk factors.…”

Section: I C R O V E S S E L D E N S I T Y M I C R O V a S C U L mentioning

confidence: 96%

“…A few reports investigated the importance of MVI in RCC and showed that vascular invasion occurring only at microscopic level was correlated with a worse outcome [12][13][14]16,18]. In the studies by Mrstik et al [18] and Yildiz et al [13], when stratifying tumour extension (pT stage) and nuclear grading against MVI, the latter retained a greater influence on disease-free survival.…”

Section: I C R O V E S S E L D E N S I T Y M I C R O V a S C U L mentioning

confidence: 99%

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

et al. 2007

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OBJECTIVE To clarify the significance of microvessel density (MVD) in a retrospective investigation the relationship between the pattern of MVD (reflecting angiogenesis), and tumour stage, grade, size, and occurrence of microvessel invasion (MVI), metastasis, and cancer‐specific survival (CSS) in patients who had surgery for renal cell carcinoma (RCC). PATIENTS AND METHODS Vessels were labelled in sections of formalin‐fixed, paraffin‐embedded tissues from 54 RCCs by CD34 immunohistochemistry. The mean MVD, expressed as the number of vessels per 10 high‐power fields (HPF, ×400) were measured for each case. In addition, all pathological slides were reviewed for the presence and absence of MVI. The prognostic value of MVD and MVI was then evaluated, and correlated with the usual prognostic variables, tumour metastasis and CSS. RESULTS In a univariate analysis of CSS, the MDV tended to be lower as stage increased from pT1 to pT3, and as grade increased from G1 to G4, although it was statistically significant only for stage (P < 0.001 and 0.050, respectively). The mean MVD was higher in 42 nonmetastatic than in 12 metastatic tumours, and in 33 tumours associated with MVI than in 21 with no MVI (P < 0.001). The mean MVD was also lower and significantly different for 28 large than 26 small tumours (P = 0.005). The survival rate of patients with tumours that were small, low‐stage, of higher MVD, with no MVI and metastasis was significantly higher than that of patients with large, high‐stage, low MVD, with MVI and metastatic tumours (all P < 0.001). MVI was significantly more common with a decreasing trend in MVD and the presence of metastasis (Spearman rank correlation rs = −0.68, P = 0.01, and rs = 0.39, P = 0.01, respectively). Independent prognostic factors in a multivariate analysis were: in all patients with RCC, tumour stage (P = 0.013) and metastasis (P = 0.028); in those with low MVD, MVI (P = 0.004) and metastases (P = 0.016); in those with no MVI, stage (P = 0.020); in those with MVI, MVD (P = 0.001); in those with no metastases, stage (P = 0.045); and in those with metastases, MVD (P < 0.001). No independent predictor was identified in patients with high MVD. In patients with no metastases there was a significantly shorter median CSS time in RCCs with low MVD and with MVI (P = 0.004 for both). Similarly, patients who had grade 3–4 tumours, vs those with lower MVD and with MVI, had a significantly shorter median CSS (P = 0.020 for MVD, and 0.01 for MVI). CONCLUSIONS This study suggested that MVD in RCC was inversely associated with MVI, tumour metastasis, patient survival and tumour diameter and stage, from the usual prognostic variables, but MVD was not an independent prognostic factor in multivariate analysis for all patients with RCC. Low MVD and the presence of MVI appears to be a marker for identifying patients with an adverse prognosis.

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“…Association of clinical and pathologic features in new prognostic scoring systems has demonstrated some utility in clinical management of patients with RCC (11,12), but tumour biology is still poorly understood. Therefore, the prognosis of the single cases of RCC sometimes remains unpredictable (13)(14)(15)(16)(17)(18), and there is a compelling need for different and new prognostic biomarkers, which may predict, at a molecular level, RCC aggressiveness and patient outcome.…”

Section: Introductionmentioning

confidence: 99%

Survivin Expression in Renal Cell Carcinoma

Zamparese

Pannone

Santoro

et al. 2008

Cancer Investigation

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Deregulated expression of inhibitors of apoptosis may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence of resistance to chemo- and radiotherapy. In this study, we have investigated, by immunohistochemical technique, the expression and potential prognostic significance of survivin in a series of 49 clear cell type renal cell carcinoma (ccRCC). Survivin expression was significantly associated with poorly differentiated, advanced stages and more aggressive ccRCCs (p < 0.05). Patients with low survivin expression had statistically significant better survival rates than patients with high survivin expression (p < 0.05). This may be relevant for follow-up protocols design and/or alternative therapeutic approaches.

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Microscopic Venous Infiltration As Predictor Of Relapse In Renal Cell Carcinoma

Cited by 51 publications

References 19 publications

Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma

Contribution of grade, vascular invasion and age to outcome in clinically localized renal cell carcinoma

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

Survivin Expression in Renal Cell Carcinoma

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