2022
DOI: 10.1101/2022.10.23.513372
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Microsecond pulse electrical stimulation modulates cell migration

Abstract: Wound healing is a complicated process for maintaining skin integrity after injury, for which electrical stimulations (ES) are ascribed to promote wound healing by facilitating cell migration. Time-shortening of the stimulation treatment from current hours to minutes for efficient wound healing but free of cell damage in return, is however rather a challenge. Here, a novel mechanism of ultrashort pulse electric filed (PEF), microsecond PEF at higher voltage, is proposed and realized to promote wound healing un… Show more

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Cited by 2 publications
(2 citation statements)
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“…Xiang et al report increased fibroblast cell migration speed with a single 100 μsPEF at 0.75 kV/cm stimulation, whereas fibroblasts exposed to 1.5 kV/cm stimulation express a remarkable decrease in migration speed. 46 When pulse parameters are selected such that a higher cell viability is maintained, μsPEF stimulation could promote an increased migration speed of primary AF cells over a long period, which has the potential to significantly reduce clinical treatment time and bolster regenerative tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…Xiang et al report increased fibroblast cell migration speed with a single 100 μsPEF at 0.75 kV/cm stimulation, whereas fibroblasts exposed to 1.5 kV/cm stimulation express a remarkable decrease in migration speed. 46 When pulse parameters are selected such that a higher cell viability is maintained, μsPEF stimulation could promote an increased migration speed of primary AF cells over a long period, which has the potential to significantly reduce clinical treatment time and bolster regenerative tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…It is established that low electric fields (either continuous or periodic) alter cell transmembrane potential, which leads to the opening of voltage-gated ion channels or changes in the enzymatic activity of phosphatases, containing a voltage-sensor domain [ 66 ]. High electric fields might have thermal effects and cause tissue damage; however, when high-intensity stimulation is applied for short intervals, it can trigger positive effects, similar to those induced by longer low electric field strength stimulation [ 67 ]. Depending on the pulsed electric field strength, the duration and the number of pulses can be reduced, providing flexibility in the development of parametric protocols ( Table 2 ) [ 68 ].…”
Section: Types Of Es Application and Their Effects Activating Cellula...mentioning
confidence: 99%