Microsphere—Toward Future of Optical Microscopes

Chen, Lianwei; Zhou, Yan; Zhou, Rui; Hong, Minghui

doi:10.1016/j.isci.2020.101211

Cited by 30 publications

(18 citation statements)

References 67 publications

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“…In the case of intracellular imaging, the objects were generally underneath lipid droplets due to the intrinsic pressure inside the cell 37 and so the droplets worked in a contact mode of microlenses 8 . To analyze their lensing effect in contact mode, the lipid droplets were extracted from the adipose cells to index matching liquid that was matched with the cytoplasm (~1.36).…”

Section: Resultsmentioning

confidence: 99%

“…The past few decades have witnessed a dramatic progress in optical imaging 8 – 10 , especially with the emerging of microsphere-assisted techniques that enable real-time and super-resolution imaging at visible wavelengths with conventional optical microscope 8 , 11 – 16 . The microspheres also provide the opportunities to take advantage of some photonic functions such as directional antennas, whispering-gallery modes, and photonic nanojets to enhance the optical signals including fluorescence 13 , 17 , upconversion emission 18 , Raman scattering 13 , 19 , and backscattering 17 , 20 .…”

Section: Introductionmentioning

confidence: 99%

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Lipid droplets as endogenous intracellular microlenses

Chen

Gong

et al. 2021

Light Sci Appl

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Using a single biological element as a photonic component with well-defined features has become a new intriguing paradigm in biophotonics. Here we show that endogenous lipid droplets in the mature adipose cells can behave as fully biocompatible microlenses to strengthen the ability of microscopic imaging as well as detecting intra- and extracellular signals. By the assistance of biolenses made of the lipid droplets, enhanced fluorescence imaging of cytoskeleton, lysosomes, and adenoviruses has been achieved. At the same time, we demonstrated that the required excitation power can be reduced by up to 73%. The lipidic microlenses are finely manipulated by optical tweezers in order to address targets and perform their real-time imaging inside the cells. An efficient detecting of fluorescence signal of cancer cells in extracellular fluid was accomplished due to the focusing effect of incident light by the lipid droplets. The lipid droplets acting as endogenous intracellular microlenses open the intriguing route for a multifunctional biocompatible optics tool for biosensing, endoscopic imaging, and single-cell diagnosis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipid droplets as endogenous intracellular microlenses

Chen

Gong

et al. 2021

Light Sci Appl

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“…A separate major direction is associated with the use of mesoscale particles in microscopy [38,39,106,172]. In the authors' opinion, the creation of mesoparticle chains with the required properties using the phase-matching mechanism that relies on the coupling of random quasi-phase-matching with the Mie resonance of the entirely disordered mesostructure is promising [173].…”

Section: Discussionmentioning

confidence: 99%

Optical Phenomena in Mesoscale Dielectric Particles

Minin

2021

Photonics

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During the last decade, new unusual physical phenomena have been discovered in studying the optics of dielectric mesoscale particles of an arbitrary three-dimensional shape with the Mie size parameter near 10 (q~10). The paper provides a brief overview of these phenomena from optics to terahertz, plasmonic and acoustic ranges. The different particle configurations (isolated, regular or Janus) are discussed, and the possible applications of such mesoscale structures are briefly reviewed herein in relation to the field enhancement, nanoparticle manipulation and super-resolution imaging. The number of interesting applications indicates the appearance of a new promising scientific direction in optics, terahertz and acoustic ranges, and plasmonics. This paper presents the authors’ approach to these problems.

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“…A separate major direction is associated with the use of mesoscale particles in microscopy [38,39,104,170]. Also a promising way from our point of view is the way of creating assembled mesoparticles with the required properties based on phase-matching mechanism that relies on the coupling of random quasi-phase-matching with the Mie resonances of the entire disordered mesostructure [171].…”

Section: Discussionmentioning

confidence: 99%

Optical phenomena in mesoscale dielectric particles

Minin¹,

Minin²

2021

Preprint

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During the last decade, new unusual physical phenomena have been discovered in studying the optics of dielectric mesoscale particles of an arbitrary three-dimensional shape with the Mie size parameter near 10 (q ~ 10). The paper provides a brief overview of these phenomena from optics to terahertz, plasmonic and acoustic ranges. The different particle configurations (isolated, regular or Janus) are discussed, and the possible applications of such mesoscale structures are briefly reviewed herein in relation to the field enhancement, nanoparticle manipulation and super-resolution imaging. The number of interesting applications indicates to a new promising scientific direction emerged in optics, terahertz and acoustic ranges, and plasmonics. In this paper we present the authors' view of these problems.

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Microsphere—Toward Future of Optical Microscopes

Cited by 30 publications

References 67 publications

Lipid droplets as endogenous intracellular microlenses

Lipid droplets as endogenous intracellular microlenses

Optical Phenomena in Mesoscale Dielectric Particles

Optical phenomena in mesoscale dielectric particles

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