Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice

Wu, Shiuan-Huei; Sun, Nan-Nong; Chau, Chi‐Fai

doi:10.1016/j.jfda.2015.08.002

Cited by 3 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The swelling behavior depends on the nature of the polymer and its solvent compatibility [ 7 ]. The results predicts that pH 1.2 allows the highest swelling rate in comparison to pH 4.5 and 7.4, owing to the inherent hydrophobic nature of chitosan that prevents rapid swelling in alkaline and neutral pH because chitosan is not soluble in neutral or basic pH range and dissolves in specific organic and inorganic solvents.…”

Section: Discussionmentioning

confidence: 99%

“…These biodegradable polymers are important in such a way that the implanted foreign materials vanish from the body as a result of their degradation. Examples of the most commonly used biodegradable polymers in biomedical applications are polylactic acid, polyethylene glycol (PEG), polyglycolic acid, poly-ɛ-caprolactone, poly-3-hydroxybutyrate, copolymers of polyglycolide, chitosan, alginate, and soy protein [ 7 ]. PEG is a biodegradable polymer with excellent properties such as biocompatibility and safety.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery

Gilani

Mir

Masood

et al. 2018

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

The purpose of this study was to fabricate a triple-component nanocomposite system consisting of chitosan, polyethylene glycol (PEG), and drug for assessing the application of chitosan-PEG nanocomposites in drug delivery and also to assess the effect of different molecular weights of PEG on nanocomposite characteristics. The casting/solvent evaporation method was used to prepare chitosan-PEG nanocomposite films incorporating piroxicam-β-cyclodextrin. In order to characterize the morphology and structure of nanocomposites, X-ray diffraction technique, scanning electron microscopy, thermogravimetric analysis, and Fourier transmission infrared spectroscopy were used. Drug content uniformity test, swelling studies, water content, erosion studies, dissolution studies, and anti-inflammatory activity were also performed. The permeation studies across rat skin were also performed on nanocomposite films using Franz diffusion cell. The release behavior of films was found to be sensitive to pH and ionic strength of release medium. The maximum swelling ratio and water content was found in HCl buffer pH 1.2 as compared to acetate buffer of pH 4.5 and phosphate buffer pH 7.4. The release rate constants obtained from kinetic modeling and flux values of ex vivo permeation studies showed that release of piroxicam-β-cyclodextrin increased with an increase in concentration of PEG. The formulation F10 containing 75% concentration of PEG showed the highest swelling ratio (3.42±0.02) in HCl buffer pH 1.2, water content (47.89±1.53%) in HCl buffer pH 1.2, maximum cumulative drug permeation through rat skin (2405.15±10.97 μg/cm) in phosphate buffer pH 7.4, and in vitro drug release (35.51±0.26%) in sequential pH change mediums, and showed a significantly (p<0.0001) higher anti-inflammatory effect (0.4 cm). It can be concluded from the results that film composition had a particular impact on drug release properties. The different molecular weights of PEG have a strong influence on swelling, drug release, and permeation rate. The developed films can act as successful drug delivery approach for localized drug delivery through the skin.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery

Gilani

Mir

Masood

et al. 2018

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

show abstract

“…Many application areas of sodium alginate-based drug-delivery systems, and these systems can be formulated as gels, matrices, membranes, nanospheres, microspheres, and others [ 2 , 81 ]. Researchers are exploring possible applications of alginates as a coating material and preparation of controlled release drug-delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

143

View full text Add to dashboard Cite

Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

show abstract

“…To formulate systems for controlled drug release, biodegradable polymers are used. Common biodegradable polymers are polyethylene glycol (PEG), chitosan (CS), poly- ε -caprolactone (PCL), soy protein, and copolymers of polyglycolide, polylactic acid (PLA), poly-3-hydroxybutyrate, polyglycolic acid (PGA), and alginate [ 4 ]. Chitosan is the second most abundantly found polysaccharide in nature and is used to design systems for drug delivery [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoclay Reinforced Ternary Blends Based on Biodegradable Polymers for Drug Delivery Application

Ali

Mir

Abid

et al. 2022

International Journal of Biomaterials

View full text Add to dashboard Cite

In this study, ternary blends based on chitosan, polyvinyl alcohol, and polyethylene glycol reinforced with organically modified montmorillonite (nanoclay) clay were synthesized. These ternary blends were evaluated as transdermal drug delivery patches using tramadol as a model drug. The FTIR study showed interaction among important functional groups and compatibility among the mixing components. Among drug-loaded formulations, composite MA12 shows maximum thermal stability with 27.9% weight residue at 540°C. The prepared formulations exhibited crystalline nature as observed by XRD analysis. SEM studies revealed that there are no gaps and cracks in prepared films and nanoclay was found dispersed in the formulations. The swelling ratio was higher in pH 1.2 as compared to pH 4.5 and pH 6.8 buffers, and there was an increase in swelling with an increase in PVA concentration. Moreover, the drug release test performed in phosphate buffer pH 6.8 showed that tramadol release from nanocomposite films increases with an increase in PEG concentration. Permeation studies indicated that the rate of permeation increased with a decrease in PVA concentration. The permeation rate was found to be higher for samples without nanoclay. The overall results suggest nanocomposite films as excellent candidates for transdermal drug delivery application.

show abstract

Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice

Cited by 3 publications

References 25 publications

Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery

Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery

Current Status of Alginate in Drug Delivery

Nanoclay Reinforced Ternary Blends Based on Biodegradable Polymers for Drug Delivery Application

Contact Info

Product

Resources

About