Microspheres for Liver Radiomicrospheres Therapy and Planning

Amor‐Coarasa, Alejandro

doi:10.25148/etd.fi13080524

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…(See Ref. [29] for a recent survey of limits.) Billions of H −− 's would be produced each year if the coupling strength were close to current limits.…”

Section: Remarks On General Higgs Sector Extensionsmentioning

confidence: 99%

Weakly-Coupled Higgs Bosons

Gunion

Willenbrock

Stange

1997

Advanced Series on Directions in High Energy Physics

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We review the search for the standard Higgs boson, the Higgs bosons of the supersymmetric standard model, and Higgs bosons from a variety of other models at present and future colliders. i 1Ĥ j 2 in the superpotential;Ĥ 1 andĤ 2 are the Higgs superfields) and m 12 = 0, so electroweak symmetry breaking does not occur. Thus the Higgs-field vacuum-expectation values, v 1 , v 2 , are naturally of the same size as the supersymmetry-breaking scale. Supersymmetry also makes the presence of fundamental scalar fields natural, although the Higgs fields are not the superpartners of any of the known fermions.In supergravity grand-unified models, electroweak symmetry breaking arises "radiatively", that is by evolving the parameters of the Higgs sector (including the soft SUSY-breaking parameters) from the GUT scale down to the weak scale via the renormalization group equations [36]. Due to the large mass of the top quark, the parameter m 2 2 is driven more rapidly towards zero (often to negative values) than are m 2 1 and m 2 12 , so that S is driven negative at the weak scale, triggering electroweak symmetry breaking. Thus, in these models, electroweak symmetry breaking is explained by the large top-quark mass (more precisely, by the large top-quark Yukawa coupling). Supergravity models can also explain why the scale of supersymmetry breaking (i.e., the scale of the soft-supersymmetrybreaking terms) is comparable to the weak scale, rather than the GUT scale; this is a natural result if supersymmetry breaking occurs via a "hidden" sector.As in the general 2HDM, the presence of two Higgs-doublet fields implies that the spectrum of Higgs particles is much richer in the minimal supersymmetric model than in the standard model. However, the two-doublet MSSM is a highly constrained version of the general 2HDM. First, the two-doublet MSSM Higgs couplings are automatically type-II, with one Higgs doublet (H 1 ) coupling only to down-type quarks and leptons, and the other (H 2 ) coupling only to up-type quarks. Secondly, in the MSSM, CP conservation in the Higgs sector is automatic (for a review and references, see [16]), and we find the previously-mentioned five physical Higgs particles: two CP -even neutral scalars, h 0 and H 0 ; a CP -odd neutral scalar (often called a pseudoscalar), A 0 ; and a pair of charged Higgs bosons, H ± . Further, due to the special form of the potential, Eq. 4, dictated by softly-broken supersymmetry, the Higgs sector is described (at tree level) by just two free parameters, only one more than the standard Higgs model. It is conventional to choose the mass of the pseudoscalar Higgs boson, m A 0 , and the ratio of the Higgs-field vacuumexpectation values, tan β ≡ v 2 /v 1 , as the free parameters. Other parameters of the model affect the Higgs sector after including loop corrections [37]; the most important of these are the top-quark and the stop-squark masses, with parameters that influence stop-squark mixing also playing a significant role.The dominant radiative corrections arise from an incomplete cance...

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“…(See Ref. [29] for a recent survey of limits.) Billions of H −− 's would be produced each year if the coupling strength were close to current limits.…”

Section: Remarks On General Higgs Sector Extensionsmentioning

confidence: 99%

Weakly-Coupled Higgs Bosons

Gunion

Willenbrock

Stange

1997

Advanced Series on Directions in High Energy Physics

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“…[1]. Here also the future experiments (ANAIS [35], DM-ICE, SABRE [36,37] , KIMS [33]) using NaI(TI) crystals hopefully will shed light on the origin of the DAMA/LIBRA modulation signal. The SABRE collaboration plans to use an active veto shield and to operate twin detectors on the northern and southern hemisphere.…”

Section: Direct Dm Searchesmentioning

confidence: 99%

Perspectives on the detection of supersymmetric Dark Matter

Boer

2018

EPJ Web Conf.

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Up to now searches for Dark Matter (DM) detection have not been successful, either because our paradigm in how DM signals should look like are wrong or the detector sensitivity is still too low in spite of the large progress made in recent years. We discuss both possibilities starting with what we know about DM from cosmology and why Supersymmetry provides such an interesting paradigm for cosmology and particle physics in order to appreciate what it means to give up this paradigm. In addition, we compare the predicted cross sections for direct and indirect DM detection with observations with emphasis on the latest developments. Especially, we discuss the possible origins of the two hotly debated candidates for a DM annihilation signal, namely the positron excess and the Fermi GeV excess, which are unfortunately incompatible with each other and more mundane astrophysical explanations exist. a EPJ Web of Conferences Figure 1. The energy components of the universe. From the ESA webpage showing the results from the precise measurements by the Planck satellite, which increase the DM content 15% in comparison with previous determinations. excellent candidate, the so-called lightest supersymmetric particle (LSP), although other candidates exist [7].But Supersymmetry has many other advantages, as will be discussed in Sect. 3. Therefore, we concentrate on supersymmetric DM. The DM searches and interpretations are discussed in Sect. 4. We will also discuss why the so-called Fermi excess in the gamma-ray sky and the AMS-02 positron excess, both discussed as signals for DM detection, can be easily (and better) explained by astrophysical origins, so they are no compelling (and especially not a consistent) argument for DM. In the conclusion (Sect. 5) we summarize why at present no DM signals have been observed, which is either because our paradigm of WIMP detection is wrong or because the experiments are not sensitive enough. In Supersymmetry the latter is possible, but future experiments will be able to cover a large region of the available parameter space. If still no DM signals are found with future experiments, the pressure to look for another paradigm will increase correspondingly.

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“…The integrity of the filters before and after use was ascertained at 50 psi pressure adopting bubble point method. 20 Sterility of the radiolabeled formulations was tested in tryptic soya broth media and fluid thioglycollate media using Himedia Labs sterility test kits. Pyrogenicity of the solutions was checked by point-of-use test system (Charles River, USA).…”

Section: Materials and Equipmentmentioning

confidence: 99%

A “mix‐and‐use” approach for formulation of human clinical doses of ¹⁷⁷Lu‐DOTMP at hospital radiopharmacy for management of pain arising from skeletal metastases

Chakraborty

Vimalnath

Rajeswari

et al. 2017

Labelled Comp Radiopharmac

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Use of bone-seeking radiopharmaceuticals is an established modality in the palliative care of pain due to skeletal metastases. Lu-DOTMP is a promising radiopharmaceutical for this application owing to the ideally suited decay properties of Lu and excellent thermodynamic stability and kinetic rigidity of the macrocyclic complex. The aim of the present study is to develop a robust and easily adaptable protocol for formulation of clinical doses of Lu-DOTMP at hospital radiopharmacy. After extensive radiochemical studies, an optimized strategy for formulation of clinical doses of Lu-DOTMP was developed, which involves simple mixing of approximately 3.7 GBq of Lu activity as LuCl solution to an aqueous solution containing 5 mg of DOTMP and 8 mg of NaHCO . The proposed protocol yielded Lu-DOTMP with>98% radiochemical purity, and the resultant formulation showed excellent in vitro stability and desired pharmacokinetic properties in animal model. Preliminary clinical investigations in 5 patients showed specific skeletal accumulation with preferential localization in the osteoblastic lesion sites and almost no uptake in soft tissue or any other major nontarget organ. The developed "mix-and-use" strategy would be useful for large number of nuclear medicine centers having access to Lu activity and would thereby accelerate the clinical translation of Lu-DOTMP.

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Microspheres for Liver Radiomicrospheres Therapy and Planning

Cited by 3 publications

References 7 publications

Weakly-Coupled Higgs Bosons

Weakly-Coupled Higgs Bosons

Perspectives on the detection of supersymmetric Dark Matter

A “mix‐and‐use” approach for formulation of human clinical doses of ¹⁷⁷Lu‐DOTMP at hospital radiopharmacy for management of pain arising from skeletal metastases

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Microspheres for Liver Radiomicrospheres Therapy and Planning

Cited by 3 publications

References 7 publications

Weakly-Coupled Higgs Bosons

Weakly-Coupled Higgs Bosons

Perspectives on the detection of supersymmetric Dark Matter

A “mix‐and‐use” approach for formulation of human clinical doses of 177Lu‐DOTMP at hospital radiopharmacy for management of pain arising from skeletal metastases

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A “mix‐and‐use” approach for formulation of human clinical doses of ¹⁷⁷Lu‐DOTMP at hospital radiopharmacy for management of pain arising from skeletal metastases