Multiple input multiple output (MIMO) antennas have recently received attention for improving wireless communication data rates in rich scattering environments. Despite this, the challenge of isolation persists prominently in compact MIMO-based electronics. Various techniques have recently emerged to address the isolation issues, among which the defected ground structure (DGS) stands out as a cost-effective solution. Additionally, selecting the appropriate feed mechanism is crucial for enhancing the key performance indicators of MIMO antennas. However, there has been minimal focus on how different feed methods impact the operation of MIMO antennas integrated with DGS. This paper begins with a comprehensive review of diverse antenna design, feeding strategies, and DGS architectures. Subsequently, the causal relationships between various feed networks and DGSs has been established through modeling, simulation, fabrication, and measurement of MIMO antennas operating within the sub-6 GHz spectrum. Particularly, dual elements of MIMO antennas grounded by a slotted complementary split ring resonator (SCSRR)-based DGS were excited using four standard feed methods: coaxial probe, microstrip line, proximity coupled, and aperture coupled feed. The influence of each feed network on the performance of MIMO antennas integrated with SCSRR-based DGSs has been thoroughly investigated and compared, leading to guidelines for feed network selection. The coaxial probe feed network provided improved isolation performance, ranging from 16.5 dB to 46 dB in experiments.The aperture and proximity-coupled feed network provided improvements in bandwidth of 38.7% and 15.6%, respectively. Furthermore, reasonable values for envelope correlation coefficient (ECC), diversity gain (DG), channel capacity loss (CCL), and mean effective gain (MEG) have been ascertained.