Microstructural abnormalities in anterior callosal fibers and their relationship with cognitive function in major depressive disorder and bipolar disorder: A tract-specific analysis study

Yamada, Shinichi; Takahashi, Shun; Ukai, Shigeo; Tsuji, Takao; Iwatani, Jun; Tsuda, Kumi; Kita, Akira; Sakamoto, Yuka; Yamamoto, Masahiro; Tomita, Masaki; Shinosaki, Kazuhiro

doi:10.1016/j.jad.2014.12.022

Cited by 61 publications

(52 citation statements)

References 61 publications

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“…An abnormal FA value reduction in the corpus callosum of BD subjects was revealed in our TBSS analysis, which was supported by many previous studies (Barnea-Goraly et al, 2009; Chaddock et al, 2009; Macritchie et al, 2010; Marlinge et al, 2014; Yamada et al, 2015). In addition, the significant correlation between the FC of the two interhemispheric clusters whose within-connectivity was lower in the SMN of BD subjects and reduced FA values in the corpus callosum of BD subjects was found in our study (Fig.…”

Section: Discussionsupporting

confidence: 92%

Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis

Ishida

Donishi

Iwatani

et al. 2017

Heliyon

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BackgroundLittle is known regarding interhemispheric functional connectivity (FC) abnormalities via the corpus callosum in subjects with bipolar disorder (BD), which might be a key pathophysiological basis of emotional processing alterations in BD.MethodsWe performed tract-based spatial statistics (TBSS) using diffusion tensor imaging (DTI) in 24 healthy control (HC) and 22 BD subjects. Next, we analyzed the neural networks with independent component analysis (ICA) in 32HC and 25 BD subjects using resting-state functional magnetic resonance imaging.ResultsIn TBSS analysis, we found reduced fractional anisotropy (FA) in the corpus callosum of BD subjects. In ICA, functional within-connectivity was reduced in two clusters in the sensorimotor network (SMN) (right and left primary somatosensory areas) of BD subjects compared with HCs. FC between the two clusters and FA values in the corpus callosum of BD subjects was significantly correlated. Further, the functional within-connectivity was related to Young Mania Rating Scale (YMRS) total scores in the right premotor area in the SMN of BD subjects.LimitationsAlmost all of our BD subjects were taking several medications which could be a confounding factor.ConclusionsOur findings suggest that interhemispheric FC dysfunction in the SMN is associated with the impaired nerve fibers in the corpus callosum, which could be one of pathophysiological bases of emotion processing dysregulation in BD patients.

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Section: Discussionsupporting

confidence: 92%

Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis

Ishida

Donishi

Iwatani

et al. 2017

Heliyon

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“…Consistent with previous studies, we observed elevated levels of irritability in BD youth and to a lesser extent in REL. As outlined above, the anterior CC has been associated with working memory performance and sustained attention . However, the hypothesis that impaired executive functions might mediate associations between aberrant WM microstructure in the anterior CC and irritability should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 97%

White matter microstructure in youth with and at risk for bipolar disorder

et al. 2020

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Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto‐limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation. Methods To determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n = 36 first‐degree relatives, REL) to youth with BD (n = 36) and healthy volunteers (n = 36, HV) using diffusion tensor imaging. Results Individuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)/corticospinal tract (CST) and the body of the corpus callosum. WM microstructure of the anterior CC showed reduced age‐related in‐creases in BD compared to REL and HV. Further, individuals with BD and REL showed in‐creased difficulties in emotion regulation, which were associated with the microstructure of the anterior thalamic radiation. Discussion Alterations in the SCR/CST and the body of the corpus callosum appear to represent a trait marker of BD, whereas changes in other WM tracts seem to be a disease state marker. Our findings also support the role of aberrant developmental trajectories of WM microstructure in the risk architecture of BD, although longitudinal studies are needed to confirm this association. Finally, our findings show the relevance of WM microstructure for difficulties in emotion regulation—a core characteristic of BD.

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“…[78][79][80][81][82] The CC modulates cognitive processes and information transfer between hemispheres. 83 One DTI study demonstrated that abnormalities in the structural integrity of the anterior genu of the CC may contribute to impairment of interhemispheric connectivity in medication-naive patients with MDD. 84 Therefore, FA reductions in the genu and body of the CC may indicate the functional impairment of frontal lobe information transfer between hemispheres and may be associated with impairment of working memory and emotion processing in patients with MDD.…”

Section: Fractional Anisotropy Reductions In the Corpus Callosummentioning

confidence: 99%

“…84 Therefore, FA reductions in the genu and body of the CC may indicate the functional impairment of frontal lobe information transfer between hemispheres and may be associated with impairment of working memory and emotion processing in patients with MDD. 83 A recent DTI study investigating the association between catechol-O-methyltransferase gene polymorphisms and white matter tract integrity in patients with MDD has found that MDD may be associated with the dysfunctional white matter changes in the CC, and the valine homozygote of catechol-O-methyltransferase gene may enhance these pathological changes. 85 Furthermore, studies by Guo and colleagues 66,86 have demonstrated that abnormalities of white matter tracts, mainly in the projection fibres and CC, may contribute to the pathogenesis of treatment-responsive MDD, 66 and that abnormalities of white matter integrity of neuronal tracts connecting 2 brain hemispheres may play a key role in the pathogenesis of TRD.…”

Section: Fractional Anisotropy Reductions In the Corpus Callosummentioning

confidence: 99%

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

Jiang

Zhao

et al. 2017

JPN

122

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Microstructural abnormalities in anterior callosal fibers and their relationship with cognitive function in major depressive disorder and bipolar disorder: A tract-specific analysis study

Cited by 61 publications

References 61 publications

Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis

Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis

White matter microstructure in youth with and at risk for bipolar disorder

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

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