Microstructural white matter damage at orbitofrontal areas in borderline personality disorder

Carrasco, José Luís; Tajima-Pozo, Kazuhiro; Dı́az-Marsá, Marina; Casado, Ana María Martín; López-Ibor, Juan J; Arrazola, Juan; Yus, Miguel

doi:10.1016/j.jad.2011.12.019

Cited by 61 publications

(52 citation statements)

References 38 publications

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“…From the structural point of view, reported white matter frontal abnormalities agree with some of the previous studies (25)(26)(27), but the observed bilateral increases in MD, mainly in gray matter, are new. Changes in MD have been previously related to gray matter changes (42) suggesting that the increases in MD in our study are probably linked to reduction in gray matter volumes in the same areas.…”

Section: Discussionsupporting

confidence: 89%

“…However, apart from weak evidence of orbitofrontal white matter deterioration in BPD (25)(26)(27), results with this modality are still scarce. Alternatively, resting-state functional MRI may be used to quantify the amplitude of blood oxygen level-dependent fluctuations, which are usually restricted to the low frequencies (e.g., .01-.1 Hz) and are commonly known as analyses of amplitude of low-frequency fluctuations (ALFF) (28).…”

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confidence: 99%

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Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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BACKGROUND: The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. METHODS: Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n 5 60 for resting and n 5 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. RESULTS: Whole-brain analyses using a p 5 .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the left hippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with the anterior cingulate. CONCLUSIONS: With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.

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Section: Discussionsupporting

confidence: 89%

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confidence: 99%

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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“…BPD in adults has been associated with decreased FA in the corpus callosum and white matter of the orbitofrontal cortical regions (voxelwise analysis; Carrasco et al, 2012), the corpus callosum and the dorsal anterior cingulate (Rüsch et al, 2007), and the cingulum and fornix (Whalley et al, 2015). Two studies in adolescents with BPD found evidence for decreased white matter integrity in the inferior longitudinal fasciculus in adolescents with BPD (not found in adults with BPD in this study ;New et al, 2013), the SLF, and fornix (Maier-Hein et al, 2014).…”

Section: Discussionsupporting

confidence: 41%

White Matter Integrity Reductions in Intermittent Explosive Disorder

Lee

Arfanakis

Evia

et al. 2016

Neuropsychopharmacol

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Intermittent explosive disorder (IED), as described in DSM-5, is the categorical expression of pathological impulsive aggression. Previous work has identified neurobiological correlates of the disorder in patterns of frontal-limbic brain activity and dysregulation of serotonergic neurotransmission. Given the importance of short-and-long range white matter connections of the brain in social and emotional behavior, studies of white matter connectivity in impulsive aggression are warranted. Diffusion tensor imaging (DTI) studies in the related conditions of antisocial and borderline personality disorder have produced preliminary evidence of disturbed white matter connectivity in these disorders, but to date there have been no DTI studies in IED. A total of 132 male and female adults between the ages of 18 and 55 years underwent Turboprop-DTI on a 3-Tesla MRI scanner. Of these, 42 subjects had IED, 40 were normal controls, and 50 were clinical psychiatric controls with psychiatric disorders without IED. All subjects were free of alcohol, psychotropic medications, or drugs of abuse. The diffusion tensor was calculated in each voxel and maps of fractional anisotropy (FA) were generated. Tract-based spatial statistics (TBSS) were used to compare FA along the white matter skeleton among the three subject groups. IED was associated with lower FA in two clusters located in the superior longitudinal fasciculus (SLF) when compared with the psychiatric and healthy controls. Impulsive aggression and borderline personality disorder, but not psychopathy or antisocial personality disorder, was associated with lower FA in the two clusters within the SLF. In conclusion, IED was associated with lower white matter integrity in long-range connections between the frontal and temporoparietal regions.

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“…The significant association mainly located in the deeper white matter (e.g., corpus callosum and the internal capsule). Interestingly, these tracts have often been reported in the literature to differ between a variety of clinical populations and healthy subjects (Carrasco et al 2012;Travers et al 2012). For examining FA, we found no significant relationship between head motion and FA after multiple comparison correction.…”

Section: Discussionmentioning

confidence: 98%

Association between In-scanner Head Motion with Cerebral White Matter Microstructure: A Multiband Diffusion-weighted MRI study

Kong

2014

Preprint

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Diffusion-weighted MRI (DW-MRI) has emerged as a promising neuroimaging technique used to depict the biological microstructural properties of the human brain white matter.However, like any other MRI technique, DW-MRI remains subject to head motion during scanning. The association between motion and diffusion metrics is rarely understood.Previous studies have indicated that there are some regions showing significant relationship with diffusion metrics from traditional DW-MRI data with relative few gradient directions (e.g., 30 directions). As imaging techniques improves, additional gradient directions can be acquired in the same scan duration without a significant loss in spatial resolution. The current study examined the association between motion and diffusion metrics with the standard pipeline, tract-based spatial statistics (TBSS), with a multiband diffusion data (i.e., 137 directions). The diffusion metrics used in this study not only the included the commonly used metrics (i.e., FA and MD) in DW-MRI studies, but also a newly proposed inter-voxel metric, local diffusion homogeneity (LDH). The positive association was observed with MD, while the negative association with LDH. No significant association between motion and FA was observed. These results indicate that there is a similar link between motion and diffusion metrics in the multiband diffusion data. Finally, the motion-diffusion association is discussed. directions). As imaging techniques improves, additional gradient directions can be acquired in the same scan duration without a significant loss in spatial resolution. The current study examined the association between motion and diffusion metrics with the standard pipeline, tract-based spatial statistics (TBSS), with a multiband diffusion data (i.e., 137 directions). The diffusion metrics used in this study not only the included the commonly used metrics (i.e., FA and MD) in DW-MRI studies, but also a newly proposed inter-voxel metric, local diffusion homogeneity (LDH). The positive association was observed with MD, while the negative association with LDH. No significant association between motion and FA was observed. These results indicate that there is a similar link between motion and diffusion metrics in the multiband diffusion data. Finally, the motion-diffusion association is discussed. PeerJ PrePrints

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Microstructural white matter damage at orbitofrontal areas in borderline personality disorder

Cited by 61 publications

References 38 publications

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

White Matter Integrity Reductions in Intermittent Explosive Disorder

Association between In-scanner Head Motion with Cerebral White Matter Microstructure: A Multiband Diffusion-weighted MRI study

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