Microstructure and mechanical properties of bacterial cellulose/chitosan porous scaffold

Nge, Thi Thi; Nogi, Masaya; Yano, Hiroyuki; Sugiyama, Junji

doi:10.1007/s10570-009-9394-x

Cited by 110 publications

(42 citation statements)

References 51 publications

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“…Permanent or chemical gels can be formed by covalently crosslinking the fibrils. Nge et al (2010) reported the crosslinking of bacterial cellulose (BC) with chitosan through carbodiimide-mediated amide binding. BC has a nonuniform pore structure and too small pores for use as tissue scaffolds (Nge et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Nge et al (2010) reported the crosslinking of bacterial cellulose (BC) with chitosan through carbodiimide-mediated amide binding. BC has a nonuniform pore structure and too small pores for use as tissue scaffolds (Nge et al 2010). Thus, they disintegrated the BC and introduced surface carboxyl groups through TEMPO mediated oxidation to develop structures suitable for this application.…”

Section: Introductionmentioning

confidence: 99%

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Controlling the elastic modulus of cellulose nanofibril hydrogels—scaffolds with potential in tissue engineering

et al. 2014

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Cellulose nanofibrils (CNF) form hydrogels at low concentrations. These hydrogels are held together by transient interactions such as entanglement of fibrils, non-specific ionic interactions and hydrogen bonds; and are thus vulnerable for changes in the chemical environment or the influence of mechanical forces. By a covalent crosslinking of the fibrils, stable permanent gels can be formed. In this study we have produced CNF by using TEMPO mediated oxidation followed by fibrillation. During this procedure, carboxyl and aldehyde groups are introduced on the CNF surfaces. The aldehyde groups are suitable sites for crosslinking, as aldehydes readily form covalent bonds to primary amines through formation of Schiff bases. For this purpose the diamines ethylenediamine and hexamethylenediamine, differing with four carbon atoms in the chain, were used as crosslinker molecules. The results show that by varying the concentration and length of the crosslinker molecules, the elastic modulus of the gels could be controlled. The reversible gels were in this way transformed to irreversible gels by a simple water based reaction. Controlling gel strength is one important premise for the use of CNF in applications such as tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Controlling the elastic modulus of cellulose nanofibril hydrogels—scaffolds with potential in tissue engineering

et al. 2014

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“…Large pores and high interconnectivities contribute to high fluxes across the materials and faster bioseparation processes. 15 Native monoliths prepared only with chitosan (CHT_N) present regular and spherical pores (data not shown); the addition of PVA facilitates the formation of monoliths (CP_N) with large and semi-spherical pores (Fig. 1A), while the copolymerization with GMA (CG_N) enables obtaining even larger and more elongated pores (Fig.…”

Section: Preparation and Characterization Of Native Chitosan-based Momentioning

confidence: 97%

Bioinspired and sustainable chitosan-based monoliths for antibody capture and release

2012

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Chitosan-based monoliths activated by plasma technology induced the coupling of a biomimetic ligand and exhibited remarkable performance for the one-step capture and recovery of antibodies.Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached -do not change the text within the PDF file or send a revised manuscript.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: advances@rsc.org Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints. Costs for reprints are below: Chitosan-based monoliths activated by plasma technology induced the coupling of a robust biomimetic ligand, previously reported as an artificial Protein A, with high yields while minimizing the environmental impact of the procedure. Due to the high porosity, good mechanical and tunable physicochemical properties of the affinity chitosan-based monoliths, it is possible to achieve high binding capacities (150 ¡ 10 mg antibody per gram support), and to recover 90 ¡ 5% of the bound protein with 98% purity directly from cell-culture extracts. Therefore, the chitosan-based monoliths prepared by clean processes exhibit a remarkable performance for the one-step capture and recovery of pure antibodies or other biological molecules with biopharmaceutical relevance. Reprint costs

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“…The microfibrillated BC (MFC) was subjected to 2,2,6,6-tetramethylpyperidine-1-oxyl radical (TEMPO)-mediated oxidation to introduce surface carboxyl groups before mixing. The composite scaffolds had a threedimensional open pore microstructure with pore sizes ranging from 120 to 280 μm with enhanced compressive moduli and strength (Nge et al, 2010).…”

Section: Nano-composite Of Bacterial Cellulose and Chitosanmentioning

confidence: 99%

Bacterial Cellulose for Skin Repair Materials

Fu¹,

Zhang²,

Zhang³

et al. 2011

Biomedical Engineering - Frontiers and Challenges

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Microstructure and mechanical properties of bacterial cellulose/chitosan porous scaffold

Cited by 110 publications

References 51 publications

Controlling the elastic modulus of cellulose nanofibril hydrogels—scaffolds with potential in tissue engineering

Controlling the elastic modulus of cellulose nanofibril hydrogels—scaffolds with potential in tissue engineering

Bioinspired and sustainable chitosan-based monoliths for antibody capture and release

Bacterial Cellulose for Skin Repair Materials

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