Severe porosity and coarse columnar grain are prone to be formed in the laser-MIG welded joint of aluminum alloy, deteriorating the strength and ductility seriously. In this study, the ultrasound was designed to assist the laser-MIG hybrid welding of aluminum alloy, and the in uence of ultrasonic vibration on weld formation, porosity, and microstructure was investigated. The weld depth was increased from 3.6 mm to 4.2 mm when external ultrasound with the pressure of amplitude transformer (PAT) of 132 N was used, indicating that the penetration ability of hybrid heat sources to the welded plate could be improved. It was attributed to the dispersion effect of ultrasound on arc plasma in the laser channel. The porosity rate was reduced from 5.66-1.05% under PAT of 132 N, because of the increase in escape velocity of bubbles. Moreover, the columnar to equiaxed transformation (CET) of grain in the weld was promoted and the width of columnar grain zone was gradually reduced with the increasing ultrasonic energy, owing to the breaking effect of cavitation and the stirring effect of acoustic stream. As a result, lower porosity rate and ner grain size led to improvement of the microhardness and the strength of weld by ultrasound. The study provides more guidance on employing ultrasound to improve the quality of welded joints.