Microstructure and rheological properties of liquid crystallines formed in Brij 97/water/IPM system

Wang, Zhongni; Diao, Zhaoyu; Liu, Feng; Li, Ganzuo; Zhang, Gaoyong

doi:10.1016/j.jcis.2005.11.021

Cited by 53 publications

(50 citation statements)

References 25 publications

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“…29 At room temperature, formulations of BRIJ, MCG, and water formed LP when water content varied between 20% and 60% and MCG content was lower than 30% (Fig. 1).…”

Section: System Characterization and Partial Phase Diagramsmentioning

confidence: 96%

See 1 more Smart Citation

Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel

Hosmer

Shin

Nornoo

et al. 2011

Journal of Pharmaceutical Sciences

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“…29 At room temperature, formulations of BRIJ, MCG, and water formed LP when water content varied between 20% and 60% and MCG content was lower than 30% (Fig. 1).…”

Section: System Characterization and Partial Phase Diagramsmentioning

confidence: 96%

“…1). Transition to HP (of the normal type) 29 was observed with water at 50% or more and MCG content up to 10%. When water was lower than 10% or MCG was used at approximately 35% and more, formation of isotropic liquid systems predominate.…”

Section: System Characterization and Partial Phase Diagramsmentioning

confidence: 99%

Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel

Hosmer

Shin

Nornoo

et al. 2011

Journal of Pharmaceutical Sciences

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“…This effect was probably due to the oleic acid having the end group -COOH. Thus, it tends to act as a co-surfactant and cooperates in reducing interfacial tension, unlike isopropyl myristate, which has a nonpolar end group, -CH3 (Wang et al, 2006). The ability of surfactants to reduce the interfacial tension between oil and water allows translucent systems to form, based on structures smaller than a quarter of the wavelength of visible light, which do not scatter it (Garti, Aserin, 1996).…”

Section: Ternary Phase Diagramsmentioning

confidence: 99%

“…degree of ethoxylation show a lower capacity to reduce the interfacial tension, because the bonding between the oxygen atoms of the surfactant and the hydrogen of water hinder their mobility toward the surface of oil droplets, providing less translucent systems (Neto et al, 2009 Some other studies have also investigated the formation of nanostructured systems by mixtures of Oleth 10 with the oil phases: isopropyl myristate and oleic acid. These studies assessed in detail the nanostructures obtained, by means of rheological and SAXS analyses (Wang et al, 2005;Wang et al, 2006). However, they did not investigate the changes that occur in these systems as the water content is increased, or the effects of using surfactants with varying degrees of ethoxylation, a characteristic described earlier that interferes directly in the structure of these systems and, consequently, in the diffusion and release of drugs incorporated in them.…”

Section: Ternary Phase Diagramsmentioning

confidence: 99%

“…However, there are few studies on liquid crystal phases produed by these surfactants for this purpose (Wang et al, 2006). In this study we used two nonionic surfactants, long chain polyoxyethylene (10) oleyl ether (Oleth 10) and polyoxypropylene, polyoxyethylene ether of cetyl alcohol , pharmacologically and toxicologically acceptable and capable of forming nanostructured systems (Ghosh et al, 2011;Wang et al, 2005;Bruschi et al, 2008;El-Hadiry et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery

Rissi

Guglielmi

Corrêa

et al. 2014

Braz. J. Pharm. Sci.

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In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.Uniterms: Ternary phase diagrams. Nanostructured systems. Small-angle X-ray scattering/profiles. Drugs/delivery systems.Neste trabalho, os sistemas nanoestruturados com diferentes níveis de organização foram obtidos através dos diagramas de fase ternários, utilizando tensoativos com de diferentes graus de lipofilicidade, o PPG-5-Ceteth-20 e o Oleth 10, e ácido oleico e miristato de isopropila como fases oleosas. Através dos diagramas foi possível observar diferenças significativas relacionadas com as características dos sistemas, devido à capacidade que o Oleth 10 (como tensoativo) e o ácido oleico (como fase oleosa) têm em diminuir a tensão interfacial, facilitando a formação de uma extensa região de sistemas transparentes. Através da microscopia de luz polarizada foi possível identificar as características isotrópicas e anisotrópicas dos sistemas, sendo posteriormente confirmadas pelas curvas de dispersão de raios X de pequeno ângulo (SAXS). Além disso, foi possível verificar que o aumento de água nas formulações proporcionou maior estruturação, permitindo a observação de picos mais estreitos e definidos nas curvas de SAXS.Unitermos: Diagramas de fases ternários. Sistemas nanoestruturados. Curvas de dispersão de raios X de pequeno ângulo/perfis. Fármacos/sistems de liberação.

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Charge‐Induced Structural Changes of Confined Copolymer Hydrogels for Controlled Surface Morphology, Rheological Response, Adhesion, and Friction

Deptula

Wade

Rogers

et al. 2021

Adv Funct Materials

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The ability to modulate polyacrylamide hydrogel surface morphology, rheological properties, adhesion and frictional response is demonstrated by combining acrylic acid copolymerization and network confinement via grafting to a surface. Specifically, atomic force microscopy imaging reveals both micellar and lamellar microphase separations in grafted copolymer hydrogels. Bulk characterization is conducted to reveal the mechanisms underlying microstructural changes and ordering of the polymer network, supporting that they stem from the balance between hydrogen bonding in the substrate‐grafted hydrogels, electrostatic interactions, and a decrease in osmotically active charges. The morphological modulation has direct impacts on the spatial distribution of surface stiffness and adhesion. Furthermore, lateral force measurements show that the microphase separations lead to speed and load‐dependent lubrication regimes as well as spatial variation of friction. A proof of concept via salt screening demonstrates the dynamic control of surface morphology and adhesion. This work advances the knowledge necessary to design complex hydrogel interfaces that enable spatial and dynamic control of surface morphology and thereby of friction and adhesion through modulation of hydrogel composition and surface confinement, which is of significance for applications in biomedical devices, soft tissue design, soft robotics, and other engineered tribosystems.

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Microstructure and rheological properties of liquid crystallines formed in Brij 97/water/IPM system

Cited by 53 publications

References 25 publications

Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel

Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel

Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery

Charge‐Induced Structural Changes of Confined Copolymer Hydrogels for Controlled Surface Morphology, Rheological Response, Adhesion, and Friction

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