Microstructure, bioactivity and osteoblast behavior of monoclinic zirconia coating with nanostructured surface

Wang, Guocheng; Meng, Fanbin; Ding, Chuanxian; Chu, Paul K.; Liu, Xuanyong

doi:10.1016/j.actbio.2009.09.021

Cited by 95 publications

(61 citation statements)

References 52 publications

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“…Thin films coated on substrates have also been used as bioactive films [23][24][25], corrosion barriers [26], thermal barriers for turbine blades [27], or as membranes for fuel cells [28]. LTD of zirconia in the form of thin films has rarely been examined.…”

Section: Introductionmentioning

confidence: 99%

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

et al. 2015

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Bulk yttria-stabilized zirconia is a well-studied material with various applications, in particular for biomedical devices. Interestingly, it is now possible to obtain thin stand-alone sheets (40 lm thick) of this material. We present a preliminary study dealing with the aging of these foils to determine whether they would be suitable for implantable neurostimulator housing. Accelerated hydrothermal aging experiments were performed at 134°C and 2 bar. Various analyses of the material were carried out, especially by atomic force microscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV-visible-near-infrared spectroscopy. The results show that the foils maintain their integrity during simulated long-term in vivo experiments, which indicates that they are not prone to fast degradation. The observed monoclinic transformation initiates from the surface and propagates into the bulk, leading to two distinct observable parts within the sheet. The aged and the nonaged parts are separated by a limit almost linear and parallel to the surface. We also show that the micro-strains are not altered significantly after 5 h accelerated aging, and that the optical properties are not modified despite structural modifications. Although further work is needed, we have shown that foils of yttria-stabilized zirconia resist accelerated aging and are thus a promising material for the fabrication of ultrathin implantable devices.

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Section: Introductionmentioning

confidence: 99%

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

et al. 2015

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“…ZrO 2 coatings and films for biomedical application have also attracted much attention. It was reported that ZrO 2 films fabricated by micro arc oxidation [19] and plasma spraying [20] were bioactive in vitro, and ZrO 2 coating prepared by dip coating in colloidal suspension can improve dental implant osteointegration in vivo in rabbits [21].…”

Section: Introductionmentioning

confidence: 99%

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Zhang

Sun

et al. 2012

Biointerphases

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Cathodic arc deposition technique was used to deposit zirconia (ZrO2) films and titania (TiO2) films on titanium (Ti) disks respectively. The surface topography was characterized by scanning electron microscopy and atomic force microscopy. The element composition of the films was detected by X-ray photoelectron spectroscopy. The phase of films was identified by thin film X-ray diffraction. The biological behavior of osteoblast-like MG63 cells cultured on Ti, TiO2 and ZrO2 was investigated and the possible signaling molecules involved was studied by the gene expressions of integrin β1, extracellular related kinase 1/2 (ERK1/2), and c-fos. The results indicated that both the TiO2 and ZrO2 films were amorphous. Scanning electron microscopy study showed that the adhesion of MG63 cells on TiO2 and ZrO2 films was significantly enhanced compared to Ti. The CCK8 assay indicated that the TiO2 and ZrO2 films promoted the proliferation of MG-63 cells. The alkaline phosphatase (ALP) activity test and the production of type collagen I (COLI) by immunofluorescence showed that both the TiO2 and ZrO2 films can enhance ALP activity and COLI expression of MG-63 cells. In addition, the ALP activity on ZrO2 films was higher than on TiO2 films at day 4, which indicate ZrO2 films may lead to promotion of a more osteoblastic phenotype of MG-63 cells than TiO2 films. Real-time polymerase chain reaction analysis demonstrated that The gene expression of integrin β1, ERK1/2, and c-fos was higher on TiO2 and ZrO2 films than on Ti. The present work suggests that the amorphous ZrO2 films produced by cathodic arc deposition may be favorable for orthopedic implant applications and worth further study.

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“…c-ZrO2 is applied in oxygen sensors, t-ZrO2 is used as high performance transformation-toughened ceramics and can catalyze ethanol formation from syngas, while m-ZrO2 will catalyze isobutanol formation from syngas and is important for gate dielectrics and bioactive coatings. [1][2][3][4][5][6][7][8][9] The tetragonal and cubic phase are not stable at room temperature under thermodynamic equilibrium, but they can be stabilized via the incorporation of divalent and trivalent cations (Mg 2+ , Ca 2+ …). 10,11 Reducing the crystallite size of ZrO2 below 30 nm can have the same effect.…”

Section: Introductionmentioning

confidence: 99%

Fast and Tunable Synthesis of ZrO₂ Nanocrystals: Mechanistic Insights into Precursor Dependence

Keukeleere¹,

Roo

Lommens³

et al. 2015

Inorg. Chem.

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ABSTRACT:In this work, ZrO2 nanocrystals (NCs) are synthesized via a solvothermal treatment in benzyl alcohol, which is an established method for the synthesis of many metal oxide nanocrystals. We found that the use of microwave heating allows for a reduction in reaction time from 2 days in the autoclave to merely 4 hours in the microwave. Furthermore, we were able to tune the crystallographic phase from pure cubic to pure monoclinic zirconia by changing the reaction mechanism through the use of a different zirconium precursor. Via GC-MS measurements we found that the release of a strong acid during synthesis controls the key mechanism behind the control over crystal phase formation. The as-synthesized ZrO2 NCs (cubic or monoclinic) are small in size (3 -10 nm), yet aggregated. However, aggregrate-free NCs are generated through a surface-functionalization with carboxylic acid ligands, providing stabilization in apolar solvents via steric hindrance. Solution 1 H NMR was used to study the details of this post-modification step and the surface chemistry of the resulting aggregate-free NCs. This led to the conclusion that not only a different crystal structure but also a different surface chemistry is obtained depending on the precursor composition.

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Microstructure, bioactivity and osteoblast behavior of monoclinic zirconia coating with nanostructured surface

Cited by 95 publications

References 52 publications

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Fast and Tunable Synthesis of ZrO₂ Nanocrystals: Mechanistic Insights into Precursor Dependence

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Microstructure, bioactivity and osteoblast behavior of monoclinic zirconia coating with nanostructured surface

Cited by 95 publications

References 52 publications

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

Assessment of ultrathin yttria-stabilized zirconia foils for biomedical applications

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Fast and Tunable Synthesis of ZrO2 Nanocrystals: Mechanistic Insights into Precursor Dependence

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Fast and Tunable Synthesis of ZrO₂ Nanocrystals: Mechanistic Insights into Precursor Dependence