Diffusion bonding of AA7075/AZ80 joint has been synthesized, studied and demonstrated to optimize the lap shear, Ram tensile and hardness properties. Response surface methodology (RSM) is applied to develop mathematical relationships between the control parameters of two factors and three-level responses. Optimization experiments were carried out to check the models’ adequacy. The results show a high degree of coincidence between the optimized and actual values, implying that the proposed models can accurately forecast lap shear, Ram tensile, and hardness properties force within the process parameter constraints of the diffusion bonding process. Scanned electron microscopic Scanning Electron Microscope (SEM) images, optical images, and radiography film photography investigations also revealed the excellent fracture resistance of the AA7075/AZ80 alloy, making it a suitable material for deployment in engineering applications.