Microstructure, In Vitro Corrosion Behavior and Cytotoxicity of Biodegradable Mg-Ca-Zn and Mg-Ca-Zn-Bi Alloys

Bakhsheshi-Rad, H.R.; Hamzah, Esah; Tok, H. Y.; Kasiri‐Asgarani, Masoud; Jabbarzare, Saeid; Medraj, Mamoun

doi:10.1007/s11665-016-2499-0

Cited by 33 publications

(15 citation statements)

References 50 publications

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“…From the Mg–Ca–Zn ternary phase diagram [ 85 ], this intermetallic phase have been identified as Mg 2 Ca and/or Ca 2 Mg 6 Zn 3 at 1 wt% addition level of Ca and Zn. A recent study on Mg–1Ca–1Zn alloy reported that the eutectic formed intermetallic consist of three lamellar structured phases (α-Mg + Mg 2 Ca + Ca 2 Mg 6 Zn 3 ) and concentrated along the grain boundaries [ 86 ]. Fig.…”

Section: Resultsmentioning

confidence: 99%

“…For the solute-lean Mg-0.5Zn-0.5Ca alloy (only 1 wt% of total alloying element), conventional slow cooling conditions would result in large and dendritic grains [ 56 ]. One of the key issues of having higher Zn or Ca contents is that these elements, on one hand, promote refinement and strength, while, on the other hand, the corrosion rate can be accelerated by undissolved Ca-rich binary or ternary secondary intermetallic phases [ 86 ]. The thermally stable Ca-rich intermetallic phases can be expected to act as galvanic sites for localized corrosion even after rolling or extrusion processes [ 92 ].…”

Section: Discussionmentioning

confidence: 99%

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In vivo performance of a rare earth free Mg–Zn–Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices

Dargusch

Balasubramani

Yang

et al. 2022

Bioactive Materials

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A magnesium alloy containing essential, non-toxic, biodegradable elements such as Ca and Zn has been fabricated using a novel twin-roll casting process (TRC). Microstructure, mechanical properties, in vivo corrosion and biocompatibility have been assessed and compared to the properties of the rare earth (RE) element containing WE43 alloy. TRC Mg-0.5 wt% Zn- 0.5 wt% Ca exhibited fine grains with an average grain size ranging from 70 to 150 μm. Mechanical properties of a TRC Mg-0.5Zn-0.5Ca alloy showed an ultimate tensile strength of 220 MPa and ductility of 9.3%. The TRC Mg-0.5Zn-0.5Ca alloy showed a degradation rate of 0.51 ± 0.07 mm/y similar to that of the WE43 alloy (0.47 ± 0.09 mm/y) in the rat model after 1 week of implantation. By week 4 the biodegradation rates of both alloys studied were lowered and stabilized with fewer gas pockets around the implant. The histological analysis shows that both WE43 and TRC Mg-0.5Zn-0.5Ca alloy triggered comparable tissue healing responses at respective times of implantation. The presence of more organized scarring tissue around the TRC Mg-0.5Zn-0.5Ca alloys suggests that the biodegradation of the RE-free alloy may be more conducive to the tissue proliferation and remodelling process.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivo performance of a rare earth free Mg–Zn–Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices

Dargusch

Balasubramani

Yang

et al. 2022

Bioactive Materials

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show abstract

“…The authors 51 referred to the study 52 , in which the in vitro cytotoxicity of Y, Nd, Dy, Pr, Gd, La, Ce, Eu, Li, and Zr was analyzed. According to work 52 , the cytotoxicity of Ce and La is strongly associated with ionic radii, therefore, the biocompatibility of alloys with the addition of Bi was lower compared to the Mg-1.2Ca-1Zn alloy 51 . In this work, the cytotoxicity of Ca-based alloys could also be related with the differences between the ionic radii of B and Au.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the biocompability and corrosion activity of resorbable CaMgZnYbBAu alloys

Szyba

Kubina

Młynarek-Żak

et al. 2022

Sci Rep

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Calcium-based alloys can be promising candidates for use as biodegradable implants because of attractive properties as mechanical, corrosive, and biocompatible. In the work, the biocompatibility authors discussed the results of the Ca32Mg12Zn38Yb18−xBx (x = 0, 1, 2, 3 at.%) and Ca32Mg12Zn38Yb18−2xBxAux (x = 1, 2 at.%) alloys. The tests were performed using a MTT assay. The corrosion behavior of such Ca-based alloys in PWE fluid at 37 °C was studied and compared with the results in Ringer’s solution from previous works. Electrochemical tests were presented by open circuit potential and potentiodynamic curves. Different concentrations of boron and gold in the alloys caused changes in the corrosion results. The best corrosion resistance in PWE solution was observed for the Ca-based alloy with 2 at.% Au due to the lowest value of the corrosion current density (jcorr), equal to 10.6 µA·cm−2. A slightly higher value of jcorr was obtained for the Ca32Mg12Zn38Yb15B3 alloy with the lowest roughness values. The results of the cytotoxicity tests also showed that the alloy with 3 at.% boron was characterized by the highest cell viability. The investigation results discussed in the work allow us to suggest that the presented calcium alloys with 3 at.% of B, and 2 at.% of Au addition may be promising materials for the use in implantology.

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“…Similar nature is also mentioned by Ascencio et al [32] in their study. Literature also illustrated that cracks are usually formed because of dehydration of deposited layers [33]. Destructive electrolytes (Cl -) of NaCl solution infiltrate through those cracks and touch material surface.…”

Section: Corrosion Morphologymentioning

confidence: 99%

Improving Corrosion Resistance of Magnesium Nanocomposites by Using Electroless Nickel Coatings

Banerjee

Sarkar²,

Sahoo³

2022

FU Mech Eng

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The present study aims at improving corrosion resistance of magnesium nanocomposites through autocatalytic Ni-P coating. Electroless Ni-P coatings with different concentration of sodium hypophosphite are deposited on 2% WC incorporated magnesium nanocomposites (AZ31-2WC) and the coated samples are further heat-treated. Basic characterizations and compositional analyses are done by using scanning electron microscope (SEM), energy dispersive x-ray analysis (EDAX), and X-ray diffraction analysis (XRD). Microhardness values of the developed materials are also evaluated. The attempt is made to improve corrosion resistance of AZ31-2WC by modifying surface roughness. Corrosion characteristics of Ni-P coated AZ31-2WC nanocomposites are examined by performing potentiodynamic polarization test and electrochemical impedance spectroscopy (EIS). Corrosion resistance improves with enhancement of surface quality. Corrosion resistance of AZ31-2WC nanocomposite also improves due to application of Ni-P coating. Finally, corrosion morphologies are scrutinized by SEM micrographs of corroded surface.

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Microstructure, In Vitro Corrosion Behavior and Cytotoxicity of Biodegradable Mg-Ca-Zn and Mg-Ca-Zn-Bi Alloys

Cited by 33 publications

References 50 publications

In vivo performance of a rare earth free Mg–Zn–Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices

In vivo performance of a rare earth free Mg–Zn–Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices

Evaluation of the biocompability and corrosion activity of resorbable CaMgZnYbBAu alloys

Improving Corrosion Resistance of Magnesium Nanocomposites by Using Electroless Nickel Coatings

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