Microstructure, Mechanical Properties and in vitro Biological Behavior of Silicon Nitride Ceramics

Guedes-Silva, C.C.; Rodas, Andrea C.D.; Silva, Antonio Carlos da; Ribeiro, Christiane; Carvalho, Flávio; Higa, Olga Zazuco; Ferreira, Thiago dos Santos

doi:10.1590/1980-5373-mr-2018-0266

Cited by 12 publications

(18 citation statements)

References 53 publications

(62 reference statements)

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“…1 that demonstrate the total α → β-Si 3 N 4 transformation after 1 h of sintering for all samples. This behaviour was similar to that found using only SiO 2 and CaO as sintering aids for silicon nitride [21], showing that TiO 2 did not damage the liquid phase characteristics needed to promote the dissolution of the α-Si 3 N 4 phase.…”

Section: Resultssupporting

confidence: 83%

“…Ions as calcium and silicon, for example, play an important role in angiogene-sis, growth and mineralization of bone tissue, inducing the precipitation of hydroxyapatite on implants surfaces and improving the collagen synthesis in osteoblasts [17][18][19][20]. A previous work [21] focused on researching the effect of SiO 2 and CaO additions on silicon nitride ceramics, demonstrating the potential of these oxides to obtain silicon nitride components for biomedical applications [21].…”

Section: Introductionmentioning

confidence: 99%

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Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Guedes-Silva

Rodas

Carvalho

et al. 2020

PAC

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Titanium, silicon and calcium ions have demonstrated positive effects in bone healing. Therefore, this paper investigates the densification, mechanical properties and in vitro biological behaviour of TiO 2 , together with SiO 2 and CaO, on silicon nitride ceramics to be used in clinical applications. The results revealed that the sintered samples reached high values of relative density and fracture toughness, non-cytotoxicity as well as good ability to promote cell proliferation and form a layer of carbonated hydroxyapatite on their surfaces, after immersion in simulated body fluid. The sample with the highest amount of TiO 2 reached the highest value of relative density and the best results of cell proliferation and fracture toughness, indicating the great potential to be explored by in vivo experiments for later application as intervertebral devices.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Guedes-Silva

Rodas

Carvalho

et al. 2020

PAC

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“…At the molecular level, all bioceramics completely interact with living tissue that may improve performance and implant lifetime by stimulating cells to replicate and function with exceptional efficiency in spite of wholly bioinert nature [12]. Precipitate formation shows that silicon nitride is a bioinert material with a good biological response [6]. Neumann et al [83] have reported as a result of in vitro studies that Si 3 N 4 has good osseointegration and biocompatibility as Al 2 O 3 .…”

Section: In-vitro Bioactivity Characterizationmentioning

confidence: 99%

“…Moreover, studies showed that Si 3 N 4 exhibits noncytotoxicity, high antibacterial function, greater new bone formation and better osseointegration in comparison to Ti and PEEK [6]. Bioactivity, which provides good bonding between tissues and the implanted materials, also necessary in most of the biological applications together with biocompatibility [7].…”

Section: Introductionmentioning

confidence: 99%

“…Simulated body fluid (SBF) with ion concentrations nearly equal to human blood plasma can reproduce apatite in vivo [9]. Si 3 N 4 is known as bioinert [6,10]; on the contrary, nowadays studies focused on the bioactivity of Si 3 N 4 [10,11]. Si 3 N 4 bioceramics have promising in vitro performance on the basis of reciprocity with living cells [12].…”

Section: Introductionmentioning

confidence: 99%

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Phase analysis, mechanical properties and in vitro bioactivity of graphene nanoplatelet-reinforced silicon nitride-calcium phosphate composites

Bozkurt

Akarsu

Akin

et al. 2021

Journal of Asian Ceramic Societies

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The aim of this study is to produce highly dense Si 3 N 4 based composites with good mechanical properties and bioactivity. Si 3 N 4 ceramics without using sintering aids, Si 3 N 4-HA and Si 3 N 4-HA-GNP based composites have been produced by spark plasma sintering (SPS) at temperatures of 1525-1550°C. The effect of reinforcement type and content on the densification behavior, phase analysis, microstructural development, mechanical properties, and in-vitro bioactivity behavior of Si 3 N 4 were systematically investigated. Monolithic Si 3 N 4 that contains a high amount of β-Si 3 N 4 phase (~87 wt%) was produced by nearly full densification (~99%). Hydroxyapatite (HA) was used as a starting powder during the preparation of binary and triple composites to provide bioactivity to Si 3 N 4 , and after sintering, HA transformed into tricalcium phosphate (β-TCP and α-TCP) polymorphs. The incorporation of GNPs had a positive effect on the stability of β-TCP phases at higher sintering temperatures. The improvement in indentation fracture toughness of the samples with GNP reinforcement was mainly attributable to pull-out and crack deflection mechanisms. In-vitro bioactivity of GNP added composites enhanced with increasing α-TCP content. More calcium phosphate-based particle formation was observed in Si 3 N 4-HA-GNP composites compared to the Si 3 N 4-HA.

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Mechanical properties andin vitrobioactivity of silicon nitride ceramics withSiO₂,CaO, andMgOadditions

2021

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Silicon nitride ceramics with SiO 2 , CaO, and MgO as sintering aids were investigated in view of biomedical applications. In the current study, samples with four different compositions were pressureless sintered at 1750 C for 1 h under a nitrogen atmosphere. The samples were evaluated concerning densification, microstructure, mechanical properties, and in vitro bioactivity. Microstructures with elongated β-Si 3 N 4 grains dispersed in an intergranular phase and with densities from 78.77 to 97.14% of the theoretical density were obtained. Higher contents of SiO 2 resulted in the best densification and mechanical properties. Besides, replacements of CaO by MgO in the initial compositions affected Young's modulus and in vitro bioactivity.Considering the samples with relative density higher than 94.14%, those with lower values of Young's modulus had lower SiO 2 /MgO ratios. After immersion in SBF (Simulated Body Fluid), the samples with high porosity and/or partial replacements of CaO by MgO had their surfaces coated with a layer rich in calcium and phosphorus, morphologically similar to hydroxyapatite. Hence, producing silicon nitride ceramics with the potential to be used as orthopedic implants must consider ideal amounts of additives. In this article, the best combination of mechanical properties and mineralization capability was reached by the composition with low content of MgO, and high content of SiO 2 and CaO.

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Microstructure, Mechanical Properties and in vitro Biological Behavior of Silicon Nitride Ceramics

Cited by 12 publications

References 53 publications

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Phase analysis, mechanical properties and in vitro bioactivity of graphene nanoplatelet-reinforced silicon nitride-calcium phosphate composites

Mechanical properties andin vitrobioactivity of silicon nitride ceramics withSiO₂,CaO, andMgOadditions

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Microstructure, Mechanical Properties and in vitro Biological Behavior of Silicon Nitride Ceramics

Cited by 12 publications

References 53 publications

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Phase analysis, mechanical properties and in vitro bioactivity of graphene nanoplatelet-reinforced silicon nitride-calcium phosphate composites

Mechanical properties andin vitrobioactivity of silicon nitride ceramics withSiO2,CaO, andMgOadditions

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Mechanical properties andin vitrobioactivity of silicon nitride ceramics withSiO₂,CaO, andMgOadditions