Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro

Abstract

The microstructure of biomedical magnesium alloys has great influence on anti-corrosion performance and biocompatibility. In practical application and for the purpose of microstructure modification, heat treatments were chosen to provide widely varying microstructures. The aim of the present work was to investigate the influence of the microstructural parameters of an Al-free Mg-Zn-Zr alloy (ZK60), and the corresponding heat-treatment-modified microstructures on the resultant corrosion resistance and biological performance. Significant enhancement in corrosion resistance was obtained in Al-free Mg-Zn-Zr alloy (ZK60) through 400 °C solid-solution heat treatment. It was found that the optimal condition of solid-solution treatment homogenized the matrix and eliminated internal defects; after which, the problem of unfavorable corrosion behavior was improved. Further, it was also found that the Mg ion-release concentration from the modified ZK60 significantly induced the cellular activity of fibroblast cells, revealing in high viability value and migration ability. The experimental evidence suggests that this system can further accelerate wound healing. From the perspective of specific biomedical applications, this research result suggests that the heat treatment should be applied in order to improve the biological performance.

Phenolic Modified Ceramic Coating on Biodegradable Mg Alloy: The Improved Corrosion Resistance and Osteoblast-Like Cell Activity

“…In this study, Mg-6Zn-0.5Zr alloy in the form of ZK60 (Zn 5.3 wt %, Zr 0.3 wt %, and balance Mg) was used as the metallic substrate, as it is a good candidate for medical applications with good biocompatibility [ 22 , 23 ]. The main alloying elements in ZK60 are zinc, participating the bone formation process, and zirconium, a trace element in our bodies.…”

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

“…The new bone volume fraction with the ARRm-H380 membrane approached almost 100% after 12 weeks implantation. Previous reports have verified that Mg ions act as a stimulator to enhance cell proliferation and migration, and that the functional biochemical stimulation of Mg ions can improve wound healing in vitro and in vivo [7,30]. To the best of our knowledge, this report is the first to discover that Mg-based materials are capable of being applied in dentistry with excellent outcomes.…”

Ag-Introduced Antibacterial Ability and Corrosion Resistance for Bio-Mg Alloys

“…Results revealed that ZK30-0.5Ag exhibited a reduced corrosion rate of 1.41±0.13 mm·year −1 , which was significantly smaller than that of ZK30 with a corrosion rate of 2.39±0.22 mm·year −1 . Compared with some other typical biodegradable Mg alloys, such as ZK60 [ 22 ] and Mg-1Ca [ 23 ], ZK30-0.5Ag exhibited an enhanced corrosion resistance with a small degradation rate, as listed in Table 1 . For extremely individual Mg alloys with particular structure, such as Mg 69 Zn 27 Ca 4 bulk metallic glass [ 24 ], it exhibited a smaller degradation rate than ZK30-0.5Ag, which could be ascribed to the fact that the amorphous structure promoted the formation of more passive oxide film on Mg matrix.…”