Microstructures, mechanical properties, and degradation behaviors of heat-treated Mg-Sr alloys as potential biodegradable implant materials

Wang, Yuxiang; Tie, Di; Guan, Renguo; Wang, Ning; Shang, Ying-Qiu; Cui, Tong; Li, Junqiao

doi:10.1016/j.jmbbm.2017.08.028

Cited by 45 publications

(32 citation statements)

References 45 publications

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“…This leads to swelling phenomenon subcutaneously and the raise of alkalinity at the site of implantation. , The fast degradation also resulted in premature loss of mechanical integrity. However, there are strategies to provide improved resistance to the corrosion and degradability of Mg including alloying treatment, , surface coating, , purification, , and Mg-based metal matrix composite. − …”

Section: Biomaterials Used In Bone Scaffoldsmentioning

confidence: 99%

Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors

Bahraminasab

Janmohammadi

Arab

et al. 2021

ACS Biomater. Sci. Eng.

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Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in resolving this complication. Therefore, this review aims to provide information on the recent advances made to utilize the potential of biomaterials for making bone scaffolds and the assisted stem cell therapy and use of biofactors for bone tissue engineering. The requirements and different types of biomaterials used for making scaffolds are reviewed. Furthermore, the importance of stem cells and biofactors (growth factors and extracellular vesicles) in bone regeneration and their use in bone scaffolds and the key findings are discussed. Lastly, some of the main obstacles in bone tissue engineering and future trends are highlighted.

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Section: Biomaterials Used In Bone Scaffoldsmentioning

confidence: 99%

Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors

Bahraminasab

Janmohammadi

Arab

et al. 2021

ACS Biomater. Sci. Eng.

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“…However, issues such as rapid corrosion, low mechanical properties, and biofilm formation have yet to be addressed 13,41,42 . Previous studies reported the addition of 0–2 wt % Sr augments the mechanical strength, corrosion resistance, and uniformity of corrosion in Sr‐containing alloys 15,29,40,43 . Based on these findings, we used 2 wt % Sr to maximize antibacterial and osteogenic properties.…”

Section: Discussionmentioning

confidence: 99%

“…To observe the microstructure, the disks were etched using an etchant composed of 3 ml picric acid (LabChem, USA), 5 ml acetic acid (Fisher, USA), and 50 ml ethanol (Decon Labs, USA) 4,25 . Next, the microstructure was observed using an optical microscope (Amscope FMA‐50, USA) and the average grain sizes were measured using the line‐intercept method (ASTM, 2013) 29 …”

Section: Methodsmentioning

confidence: 99%

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

Aboutalebianaraki

Zeblisky

Sarker

et al. 2022

J Biomedical Materials Res

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The aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg‐Sc‐Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg‐Sc‐Sr alloy with human bone marrow‐derived mesenchymal stromal cells showed a high degree of biocompatibility (>90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg‐Sc‐Sr alloy heat‐treated at 400°C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg‐Sc‐Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate‐screws or intramedullary nails.

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“…Alloying and heat treatment are the *Corresponding author: e-mail addresses: xbxbzhang2003@163.com , xbzhang@njit.edu.cn common methods to improve mechanical properties of magnesium alloys. It has been reported that Zn, Ca, Sr, Zr, et al can significantly strengthen biomedical magnesium alloys mainly due to solution strengthening and grain refinement strengthening [10][11][12][13]. Solid solution treatment makes the alloying elements dissolve into matrix, and thus leads to solution strengthening [14].…”

Section: Introductionmentioning

confidence: 99%