“…Similar to limbs, the penis consists of skin, blood vessels, nerves, cavernous bodies, albuginea, and urethral mucosa, making penile transplantation a composite tissue transplantation [ 14 ], and the rejection reactions are usually more serious than in single organ transplantation [ 15 , 16 ]. Results from animal studies have shown that penis autotransplantations had a high success rate; however, allogeneic penis transplantation still remains a challenge for clinicians [ 17 , 18 ]. Penis defects do not endanger the life of the patients but cause profound psychological problems that greatly affect the patients' quality of life.…”