Microsurgical therapy of pituitary adenomas

Mortini, Pietro; Barzaghi, Lina Raffaella; Albano, Luigi; Panni, Pietro; Losa, Marco

doi:10.1007/s12020-017-1458-3

Cited by 67 publications

(52 citation statements)

References 51 publications

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“…Postoperative permanent DI is relatively rare in patients with pituitary adenoma [ 14 ]. Mortini et al [ 16 ] reported that permanent DI occurred in 0.9% of patients. Permanent DI occurs when there is loss of 85% or more of the hypothalamic magnocellular neurons.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Posterior Pituitary Bright Spot on Magnetic Resonance Imaging (MRI) and Postoperative Diabetes Insipidus for Pituitary Adenoma Patients

et al. 2018

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BackgroundThis study is to investigate the predictive value of posterior pituitary bright spot (PPBS) on magnetic resonance imaging (MRI) for postoperative diabetes insipidus (DI) in patients with pituitary adenoma.Material/MethodsThis was a retrospective study. In total, 65 patients with pituitary adenoma who underwent transsphenoidal surgery were enrolled. Before surgery, all patients had MRI examinations. The length of pituitary stalk and position of PPBS in T1WI sagittal and coronal sections were analyzed. The volume and height of the tumor was calculated in enhanced T1WI. Urine volume was monitored to analyze the clinical factors contributing to DI.ResultsAmong the 65 cases of pituitary adenoma, there were 54 cases of positive PPBS and 11 cases of negative PPBS. There were 32 cases of transient DI, and among these, 22 cases were positive PPBS and 10 cases were negative PPBS. However, there were 33 cases without DI, and among these, 32 cases were positive PPBS and one case was negative PPBS. The negative PPBS was significantly higher in cases with DI, compared with positive PPBS (P<0.05). Logistic regression showed that preoperative negative PPBS was an important predictor for postoperative DI (P<0.05).ConclusionsPostoperative DI should be considered when there is negative preoperative PPBS on MRI. Also, severe pituitary stalk compression indicates higher risk of postoperative DI.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Posterior Pituitary Bright Spot on Magnetic Resonance Imaging (MRI) and Postoperative Diabetes Insipidus for Pituitary Adenoma Patients

et al. 2018

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“…The data presented convincingly show, which excellent results can be achieved with a microsurgical technique by an experienced surgeon in a specialized center with a high case load. Moreover, even the rare entities of pituitary adenomas, such as thyrotropinomas, are represented in impressive numbers [1]. The data furthermore show that adaption of the endoscopic method is not necessarily required, that in contrast, impressive results can be obtained by using microsurgical excellency and that microsurgery is not at all outdated in the therapy of pituitary tumors.…”

mentioning

confidence: 85%

“…In this article [1], Mortini et al review their extensive experience with the surgical treatment of pituitary adenomas. Their results, in terms of tumor resection and normalization rates of hormonal oversecretion are outstanding, while the complication rate is minimal.…”

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confidence: 99%

Comment on Microsurgical therapy of pituitary adenomas

Buchfelder

2018

Endocrine

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“…This framework differs from the traditional model of pharmacological trials to accommodate the distinct way surgical developments occur, particularly since individual operator skill and technique modifications at the early stages can differentially impact outcomes. [ 46 ]. A subsequent paper introduced Stage 0, a preclinical stage, for testing involving cadavers, animals, or simulations, while another clarified the use of the IDEAL framework in surgical device development [ 25 , 56 ].…”

Section: Introductionmentioning

confidence: 99%

The IDEAL framework in neurosurgery: a bibliometric analysis

et al. 2020

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Background The Idea, Development, Exploration, Assessment and Long-term study (IDEAL) framework was created to provide a structured way for assessing and evaluating novel surgical techniques and devices. Objectives The aim of this paper was to investigate the utilization of the IDEAL framework within neurosurgery, and to identify factors influencing implementation. Methods A bibliometric analysis of the 7 key IDEAL papers on Scopus, PubMed, Embase, Web of Science, and Google Scholar databases (2009–2019) was performed. A second journal-specific search then identified additional papers citing the IDEAL framework. Publications identified were screened by two independent reviewers to select neurosurgery-specific articles. Results The citation search identified 1336 articles. The journal search identified another 16 articles. Following deduplication and review, 51 relevant articles remained; 14 primary papers (27%) and 37 secondary papers (73%). Of the primary papers, 5 (36%) papers applied the IDEAL framework to their research correctly; two were aligned to the pre-IDEAL stage, one to the Idea and Development stages, and two to the Exploration stage. Of the secondary papers, 21 (57%) explicitly discussed the IDEAL framework. Eighteen (86%) of these were supportive of implementing the framework, while one was not, and two were neutral. Conclusion The adoption of the IDEAL framework in neurosurgery has been slow, particularly for early-stage neurosurgical techniques and inventions. However, the largely positive reviews in secondary literature suggest potential for increased use that may be achieved with education and publicity.

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Microsurgical therapy of pituitary adenomas

Abstract: In experienced hands, transsphenoidal microsurgery for PAs achieves remission in most patients with a low complication rate. Pituitary function is preserved in most cases and can recover in more than one-third of patients with preoperative hypopituitarism.

Cited by 67 publications

References 51 publications

The Relationship Between Posterior Pituitary Bright Spot on Magnetic Resonance Imaging (MRI) and Postoperative Diabetes Insipidus for Pituitary Adenoma Patients

The Relationship Between Posterior Pituitary Bright Spot on Magnetic Resonance Imaging (MRI) and Postoperative Diabetes Insipidus for Pituitary Adenoma Patients

Comment on Microsurgical therapy of pituitary adenomas

The IDEAL framework in neurosurgery: a bibliometric analysis

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