Microtia Reconstruction

Bly, Randall A.; Bhrany, Amit D.; Murakami, Craig S.; Sie, Kathleen C.Y.

doi:10.1016/j.fsc.2016.06.011

Cited by 92 publications

(96 citation statements)

References 36 publications

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“…A total of 75-90% of microtia is accompanied with aural atresia with a variety of middle ear abnormalities, causing a fixed congenital hearing loss. 10,11 The inner ear is not affected. Newborn hearing tests can be carried out in all patients with a patent ear canal.…”

Section: Hearingmentioning

confidence: 99%

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Auricular reconstruction

Cubitt

Chang

Liang

et al. 2019

J Paediatrics Child Health

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External ear abnormalities are common. These may affect ear shape, size, prominence and degree of development. They may also be associated with hearing loss. The early identification and management of hearing loss is essential. There are several options for reconstruction of the external ear using both autologous and non‐autologous techniques. The aim of this article is to outline the different reconstructive options.

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Section: Hearingmentioning

confidence: 99%

“…At birth, a microtia patient should be carefully examined for the presence or absence of an external auditory meatus. A total of 75–90% of microtia is accompanied with aural atresia with a variety of middle ear abnormalities, causing a fixed congenital hearing loss . The inner ear is not affected.…”

Section: Hearingmentioning

confidence: 99%

Auricular reconstruction

Cubitt

Chang

Liang

et al. 2019

J Paediatrics Child Health

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“…Preoperative imaging of temporal bone morphology is performed at approximately 5 years of age to determine surgical candidacy. 16 Earlier imaging may not be accurate as pneumatization of the mastoid bone and maturation of the external ear is still ongoing, thus unnecessarily providing radiation exposure to the child's brain.…”

Section: Radiographic Imagingmentioning

confidence: 99%

“…The primary goals of auricular repair and atresiaplasty are to rehabilitate acoustic function to near normal status and improve cosmetic appearance. 9,16 Hearing restoration and ear reconstruction can then secondarily improved speech, school performance, social acceptance, and psychoemotional development. 9,16 Indications for surgical microtia repair depend on the severity of the deformity and associated anomalies.…”

Section: Goals and Indications Of Repairmentioning

confidence: 99%

“…9,16 Hearing restoration and ear reconstruction can then secondarily improved speech, school performance, social acceptance, and psychoemotional development. 9,16 Indications for surgical microtia repair depend on the severity of the deformity and associated anomalies. Patients with high-grade microtia (grades 3-4), a Jahrsdoerfer 18 score less than 5, abnormal cochlear function, and no apparent middle ear space are not good candidates for atresiaplasty as corrective surgery would unlikely benefit hearing.…”

Section: Goals and Indications Of Repairmentioning

confidence: 99%

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Otologic and Audiology Concerns of Microtia Repair

Ali

Mohan

Liu

2017

Seminars in Plastic Surgery

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Microtia is a congenital auricular deformity that commonly presents with associated congenital aural atresia. The most acute concern in these patients is concomitant hearing loss at birth. A team-based approach by plastic surgeons and otologists is necessary to address both the otologic and audiologic concerns of microtia and atresia. Hearing rehabilitation is imperative; yet it should not compromise the aesthetic components of reconstruction and vice versa. Here, the authors propose a framework to evaluate and manage patients with microtia and atresia with the goal of optimizing functional and cosmetic outcomes.

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Bioprinting of Cartilaginous Auricular Constructs Utilizing an Enzymatically Crosslinkable Bioink

Fisch

Broguière

Finkielsztein

et al. 2021

Adv Funct Materials

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Bioprinting of functional tissues could overcome tissue shortages and allow a more rapid response for treatments. However, despite recent progress in bioprinting, and its outstanding ability to position cells and biomaterials in a precise 3D manner, its success has been limited, due to insufficient maturation of constructs into functional tissue. Here, a novel calcium‐triggered enzymatic crosslinking (CTEC) mechanism for bioinks based on the activation cascade of Factor XIII is presented and utilized for the biofabrication of cartilaginous constructs. Hyaluronan transglutaminase (HA‐TG), an enzymatically crosslinkable material, has shown excellent characteristics for chondrogenesis and builds the basis of the CTEC bioink. The bioink supports tissue maturation with neocartilage formation and stiffening of constructs up to 400 kPa. Bioprinted constructs remain stable in vivo for 24 weeks and bioprinted auricular constructs transform into cartilaginous grafts. A major limitation of the current study is the deposition of collagen I, indicating the maturation toward fibrocartilage rather than elastic cartilage. Shifting the maturation process toward elastic cartilage will therefore be essential in order for the developed bioinks to offer a novel tissue engineered treatment for microtia patients. CTEC bioprinting furthermore opens up use of enzymatically crosslinkable biopolymers and their modularity to support a multitude of tissues.

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Microtia Reconstruction

Cited by 92 publications

References 36 publications

Auricular reconstruction

Auricular reconstruction

Otologic and Audiology Concerns of Microtia Repair

Bioprinting of Cartilaginous Auricular Constructs Utilizing an Enzymatically Crosslinkable Bioink

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