Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma

Han, Xiangrui; Sekino, Yohei; Babasaki, Takashi; Goto, Keisuke; Inoue, Shogo; Hayashi, Tetsutaro; Teishima, Jun; Sakamoto, Naoya; Sentani, Kazuhiro; Oue, Naohide; Yasui, Wataru; Matsubara, Akio

doi:10.1016/j.urolonc.2020.02.010

Cited by 22 publications

(20 citation statements)

References 37 publications

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“…Of the five autophagy‐related lncRNAs in the ALPS model, only MAPT‐AS1, LINC0187 and AL122010.1 have been studied in breast cancer or other cancers. MAPT‐AS1 is reported as an independent prognostic marker of clear cell renal cell carcinoma (ccRCC), inhibiting the proliferation and invasion of ccRCC 28 . Likewise, Wang et al also reported MAPT‐AS1 being a kind of lncRNA, which exists in the antisense chain of microtubule‐associated protein tau promoter.…”

Section: Discussionmentioning

confidence: 98%

Identification of autophagy‐related long non‐coding RNA prognostic signature for breast cancer

Zhu

et al. 2021

J Cellular Molecular Medi

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Autophagy‐related long non‐coding RNAs (lncRNAs) disorders are related to the occurrence and development of breast cancer. The purpose of this study is to explore whether autophagy‐related lncRNA can predict the prognosis of breast cancer patients. The autophagy‐related lncRNAs prognostic signature was constructed by Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression. We identified five autophagy‐related lncRNAs (MAPT‐AS1, LINC01871, AL122010.1, AC090912.1, AC061992.1) associated with prognostic value, and they were used to construct an autophagy‐related lncRNA prognostic signature (ALPS) model. ALPS model offered an independent prognostic value (HR = 1.664, 1.381‐2.006), where this risk score of the model was significantly related to the TNM stage, ER, PR and HER2 status in breast cancer patients. Nomogram could be utilized to predict survival for patients with breast cancer. Principal component analysis and Sankey Diagram results indicated that the distribution of five lncRNAs from the ALPS model tends to be low‐risk. Gene set enrichment analysis showed that the high‐risk group was enriched in autophagy and cancer‐related pathways, and the low‐risk group was enriched in regulatory immune‐related pathways. These results indicated that the ALPS model composed of five autophagy‐related lncRNAs could predict the prognosis of breast cancer patients.

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Section: Discussionmentioning

confidence: 98%

Identification of autophagy‐related long non‐coding RNA prognostic signature for breast cancer

Zhu

et al. 2021

J Cellular Molecular Medi

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“…showed that tau expression levels vary in different cancer types and high tau expression levels correlate with increased patient survival [ 82 ]. Another study found that MAPT knockdown enhanced cell growth and invasion and suggested that tau may be a tumour-suppressive protein in clear cell renal cell carcinoma [ 95 ]. The finding that MAPT mutations increase the risk of developing cancer suggests that tau mutations may result in loss of a tumour-suppressive function [ 223 ].…”

Section: Aβ and Tau May Function As Tumour Suppressorsmentioning

confidence: 99%

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

2020

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Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development. Recent research, however, shows that these proteins have been highly conserved throughout evolution and may have crucial, physiological roles. Such functions may be lost during AD progression or be unintentionally disrupted by tau- or Aβ-targeting therapies. Tau has been revealed to be more than a simple stabiliser of microtubules, reported to play a role in a range of biological processes including myelination, glucose metabolism, axonal transport, microtubule dynamics, iron homeostasis, neurogenesis, motor function, learning and memory, neuronal excitability, and DNA protection. Aβ is similarly multifunctional, and is proposed to regulate learning and memory, angiogenesis, neurogenesis, repair leaks in the blood–brain barrier, promote recovery from injury, and act as an antimicrobial peptide and tumour suppressor. This review will discuss potential physiological roles of tau and Aβ, highlighting how changes to these functions may contribute to pathology, as well as the implications for therapeutic development. We propose that a balanced consideration of both the physiological and pathological roles of tau and Aβ will be essential for the design of safe and effective therapeutics.

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“…For instance, prevalence of germline mutations in BUB1B in individuals with early-onset colorectal cancer [13]. MAPT is a promising independent prognostic marker and tumor suppressive protein of clear cell renal cell carcinoma [14]. LncRNA TTN-AS1 regulates RRM2 to promote breast cancer progression [15].…”

Section: Resultsmentioning

confidence: 99%

Membrane Protein Metabolism in UNG-Activated NCAPH and RFC4 Subnetworks for Viral HCC|blood Cancer Development Via Inside-Out Microtubule Binding

Wang¹,

Chen²,

Feng³

et al. 2020

Preprint

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Background: Our aim is to compute NCAPH and RFC4 subnetworks containing CDKN3 (feedback) for the novel molecular and cellular mechanisms of HCC (HBV or HCV) related cancer development from high UNG-activated upstream network.Methods: Non-SMC condensin I complex subunit H (NCAPH) and replication factor C subunit 4 (RFC4) common molecular and knowledge subnetworks containing cyclin-dependent kinase inhibitor 3-CDKN3 (feedback) related to cancer by references were identified in HCC (HBV or HCV), based on our established significant high expression uracil DNA glycosylase (UNG)-activated upstream Gene (protein) reconstruction network inference (GRNInfer) and Database for Annotation, Visualization and Integrated Discovery (DAVID).Results: Our results show the common molecules MAPT interaction with CDKN3 with RRM2 with HIST1H3H from UNG-activated upstream GRNInfer database; The common biological process and molecular function of MAPT as microtubule binding; HIST1H3H as cellular protein metabolic process from UNG-activated upstream DAVID database; The common cellular component of UNG, NCAPH, CDKN3, RRM2, HIST1H3H at nucleus; NCAPH, HIST1H3H at membrane; The common tissue distributions of NCAPH and RFC4 in Leukemiapromyelocytic(hl60), leukemialymphoblastic(molt4), etc.Conclusions: We propose and mutual positively verify membrane protein metabolism in UNG-activated NCAPH and RFC4 subnetworks for viral HCC|blood cancer development via inside-out microtubule binding.

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Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma

Cited by 22 publications

References 37 publications

Identification of autophagy‐related long non‐coding RNA prognostic signature for breast cancer

Identification of autophagy‐related long non‐coding RNA prognostic signature for breast cancer

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Membrane Protein Metabolism in UNG-Activated NCAPH and RFC4 Subnetworks for Viral HCC|blood Cancer Development Via Inside-Out Microtubule Binding

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