Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ function

Ilan, Yaron

doi:10.1007/s11010-022-04513-1

Cited by 25 publications

(20 citation statements)

References 284 publications

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“…Moreover, nanoscale functions for therapeutics controlled by light can be considered [43]. The mathematical description of energy transfer in cells samples is attractive not only for explaining optical damage [44], but energy distributions associated with biological functions involved in diseases, like viral infections or cancer [45]. Furthemore, fractional differential systems also can describe electrical activity in human skin [46] and cellular reproduction [47].…”

Section: = -mentioning

confidence: 99%

Spatially modulated ablation driven by chaotic attractors in human lung epithelial cancer cells

Martines-Arano,

Valdivia-Flores,

Castillo-Cruz

et al. 2024

Biomed. Phys. Eng. Express

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A significant modification in photoinduced energy transfer in cancer cells is reported by the assistance of a dynamic modulation of the beam size of laser irradiation. Human lung epithelial cancer cells in monolayer form were studied. In contrast to the quantum and thermal ablation effect promoted by a standard focused Gaussian beam, a spatially modulated beam can caused around 15% of decrease in the ablation threshold and formation of a ring-shaped distribution of the photothermal transfer effect. Optical irradiation was conducted in A549 cells by a 532 nm single-beam emerging from a Nd:YVO4 system. Ablation effects derived from spatially modulated convergent waves were controlled by an electrically focus-tunable lens. The proposed chaotic behavior of the spatial modulation followed an Arneodo chaotic oscillator. Fractional dynamic thermal transport was analyzed in order to describe photoenergy in propagation through the samples. Immediate applications of chaos theory for developing phototechnology devices driving biological functions or phototherapy treatments can be considered.

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Section: = -mentioning

confidence: 99%

Spatially modulated ablation driven by chaotic attractors in human lung epithelial cancer cells

Martines-Arano,

Valdivia-Flores,

Castillo-Cruz

et al. 2024

Biomed. Phys. Eng. Express

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“…3 Biological systems are characterized by variability in genomes, cells, and whole organs. [50][51][52][53][54][55][56][57][58][59][60][61][62][63] Such variations include heart rate, blood pressure, gait, respiration, and brain function. [64][65][66][67][68][69] Adaptability and flexibility are essential for systems' proper operation under continuous internal and external perturbations, according to the CDP.…”

Section: An Improved Diagnosis Model Based On Co-pilotingmentioning

confidence: 99%

Department of Medicine 2040: Implementing a Constrained Disorder Principle-Based Second-Generation Artificial Intelligence System for Improved Patient Outcomes in the Department of Internal Medicine

Ilan

2023

INQUIRY

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Internal medicine departments must adapt their structures and methods of operation to accommodate changing healthcare systems. The present paper discusses some challenges departments of medicine face as healthcare providers and consumers continue to change. A co-pilot model is described in this article for augmenting physicians rather than replacing them. The paper presents the co-pilot models to improve diagnoses, treatments, and monitoring. Personalized variability patterns based on the constrained-disorder principle (CDP) are described to assess chronic therapies’ effectiveness in improving patient outcomes. Based on CDP-based enhanced digital twins, this paper presents personalized treatments and follow-ups that improve diagnosis accuracy and therapy outcomes. While maintaining their professional values, departments of internal medicine must respond proactively to the needs of patients and healthcare systems. To meet the needs of patients and healthcare systems, they must strive for medical professionalism and adapt to the dynamic environment.

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“…Microtubules are the essential components of the cytoskeleton and play a vital role in many cellular functions, such as cell motility, intracellular transport, mitosis, and cell signaling. − They are composed of α-tubulin and β-tubulin dimers, which polymerize and depolymerize readily in cells . Thus, microtubules are considered to be an important target for anticancer drugs, such as microtubule targeting agents (MTAs), − which can interfere with microtubule dynamics, leading to mitotic blockade and cell apoptosis .…”

Section: Introductionmentioning

confidence: 99%

X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma

et al. 2023

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A series of novel indole analogues were discovered as colchicinebinding site inhibitors of tubulin. Among them, 3a exhibited the highest antiproliferative activity (average IC 50 = 4.5 nM), better than colchicine (IC 50 = 65.3 nM). The crystal structure of 3a in complex with tubulin was solved by X-ray crystallography, which explained the improved binding affinity of 3a to tubulin and thus its higher anticancer activity (IC 50 = 4.5 nM) than the lead compound 12b (IC 50 = 32.5 nM). In vivo, 3a (5 mg/kg) displayed significant antitumor efficacy against B16-F10 melanoma with a TGI of 62.96% and enhanced the antitumor efficacy of a small-molecule PD-1/PD-L1 inhibitor NP19 (TGI = 77.85%). Moreover, 3a potentiated the antitumor immunity of NP19 by activating the tumor immune microenvironment, as demonstrated by the increased tumor-infiltrating lymphocytes (TIL). Collectively, this work shows a successful example of crystal structure-guided discovery of a novel tubulin inhibitor 3a as a potential anticancer and immune-potentiating agent.

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Microtubules as a potential platform for energy transfer in biological systems: a target for implementing individualized, dynamic variability patterns to improve organ function

Cited by 25 publications

References 284 publications

Spatially modulated ablation driven by chaotic attractors in human lung epithelial cancer cells

Spatially modulated ablation driven by chaotic attractors in human lung epithelial cancer cells

Department of Medicine 2040: Implementing a Constrained Disorder Principle-Based Second-Generation Artificial Intelligence System for Improved Patient Outcomes in the Department of Internal Medicine

X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma

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