Microvascular Anastomosis Using 2-Octyl Cyanoacrylate in the Rat Femoral Artery

Hall, Wesley W.; Wrye, Scott W.; Banducci, Dennis R.; Ehrlich, Paul R.

doi:10.1097/00000637-200044050-00008

Cited by 39 publications

(27 citation statements)

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“…Although this octyl 2-cyanoacrylate is only approved for external use, it has been reported to be effective in animal models of anastomoses of femoral arteries. 36,37 In those studies the early results were very encouraging, with effective closure strength and no tissue reaction. The breaking strength of the octyl 2-cyanoacrylate is reported to be 3 times that of butyl cyanoacrylate and close to that of 5-0 monofilament nylon sutures in skin closure.…”

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confidence: 97%

Octyl 2-Cyanoacrylate for Repair of Peripheral Nerve

Piñeros-Fernandez

Rodeheaver

2005

Annals of Plastic Surgery

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The repair of peripheral nerves with sutures is time consuming. The aim of this study was to evaluate the benefits and functional outcome of repairing nerves with octyl 2-cyanoacrylate adhesive. The right peroneal nerve of 64 male, Lewis rats was sectioned and repaired. The rats were randomized into 3 experimental groups: A (n = 27), using only octyl 2-cyanoacrylate; B (n = 27), using 4, 10-0 nylon sutures; and C (n = 10), a sham operation. The recovery of nerve function was quantified through walking-track analyses; group A showed faster return of nerve function than B, especially at 15 days (P < 0.017). Histologic analysis showed a greater axonal regeneration in group A versus group B and no indication of tissue toxicity in group A. No dehiscence occurred during the 6-month study. Use of adhesive shortened the anastomosis time from 12 minutes to 4 minutes. These results indicate that the use of octyl 2-cyanoacrylate adhesive for nerve anastomoses is safe and effective and may have benefits compared with the use of sutures.

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confidence: 97%

Octyl 2-Cyanoacrylate for Repair of Peripheral Nerve

Piñeros-Fernandez

Rodeheaver

2005

Annals of Plastic Surgery

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“…29 Various potential uses of cyanoacrylate adhesives have been reported in animal studies ranging from completely sutureless anastomoses with glue only 67 or glue with absorbable biostents 67,68 to reduced suture anastomoses with adhesive and hemostasis. [69][70][71][72] Although these studies have gone some way to demonstrate safety and increased speed and reliability of anastomoses, some studies have shown significant histological foreign body reactions in vessels walls. 73 One report in the literature advocates use of a coating of cyanoacrylate to give collapsed veins added rigidity thereby reducing the risks of suturing the back wall 74 and at least one report of using cyanoacrylates as haemostatic agent in anastomoses in humans exists.…”

Section: Adhesivesmentioning

confidence: 99%

Technology‐assisted and sutureless microvascular anastomoses: Evidence for current techniques

et al. 2011

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Of the available forms of assisted microvascular anastomoses, there is level 2b evidence suggesting a positive outcome with the use of the Unilink™/3M™ coupler and the Autosuture™ VCS® clip applicator. Other techniques such as cyanoacrylates, fibrin glues, the Medtronic™ U-Clip®, and laser bonding have low levels of evidence supporting their use. Further research is required to establish any role for these techniques.

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“…These disadvantages have prevented further use of cyanoacrylates for vascular anastomosis in the clinical setting. Recent reports suggest that 2-octyl-cyanoacrylate may be less toxic, but the FDA has so far approved it for topical use only in wound closure 75,76 . With any type of adhesive, proper adjustment of the vessel ends before application of the adhesive is essential to avoid the danger of glue entering the vessel lumen.…”

Section: Adhesivesmentioning

confidence: 99%

Non-suture methods of vascular anastomosis

Zeebregts¹,

Dungen³

et al. 2003

British Journal of Surgery

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The non-suture techniques can be categorized into five groups based on the materials used: rings, clips, adhesives, stents and laser welding. With all these techniques a faster and less traumatic anastomosis can be made compared with sutures. However, each device is associated with technique-related complications. As a consequence, suturing continues to be the standard approach. The disadvantages of the non-suture techniques include: rigidity and a non-compliant anastomosis with rings; toxicity, leakage and aneurysm formation with adhesives; early occlusion with stents; cost, reduced strength in larger-sized vessels and demand for surgical skills with laser welding. Further refinement is needed before widespread adoption of these techniques can occur. Clips, however, may be particularly promising but long-term evaluation is required.

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Microvascular Anastomosis Using 2-Octyl Cyanoacrylate in the Rat Femoral Artery

Cited by 39 publications

References 0 publications

Octyl 2-Cyanoacrylate for Repair of Peripheral Nerve

Octyl 2-Cyanoacrylate for Repair of Peripheral Nerve

Technology‐assisted and sutureless microvascular anastomoses: Evidence for current techniques

Non-suture methods of vascular anastomosis

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