2009
DOI: 10.1536/ihj.50.407
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Microvascular Angina. The Possible Role of Inflammation, Uric Acid, and Endothelial Dysfunction

Abstract: SummaryMicrovascular angina is a condition characterized by angina-like chest pain and normal coronary angiography. Endothelial dysfunction and systemic inflammation with elevated serum high-sensitive C-reactive protein (hsCRP) levels play a role in its pathogenesis. This study aimed to explore the possible relation between CRP, brachial flowmediated dilatation (FMD), and microvascular angina.We included 21 patients with attacks of chest pain diagnosed as microvascular angina (study group) and 10 normal asympt… Show more

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Cited by 20 publications
(15 citation statements)
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“…Retrospective data of individuals with coronary artery disease diagnosed by coronary angiography showed no effect of uric acid on cardiovascular mortality, but on all-cause mortality [38], and uric acid failed to prove itself as a clinical marker of coronary artery disease [85]. A study in 21 individuals with microvascular angina, manifested by chest pain and objective signs of myocardial ischemia, and normal coronary angiography, failed to show an effect of uric acid on endothelial function [86]. Cross-sectional data of 1.200 Korean adults failed to show an effect of hyperuricemia on endothelial function/arterial stiffness, as represented by pulse wave velocity [87].…”
Section: Discussionmentioning
confidence: 99%
“…Retrospective data of individuals with coronary artery disease diagnosed by coronary angiography showed no effect of uric acid on cardiovascular mortality, but on all-cause mortality [38], and uric acid failed to prove itself as a clinical marker of coronary artery disease [85]. A study in 21 individuals with microvascular angina, manifested by chest pain and objective signs of myocardial ischemia, and normal coronary angiography, failed to show an effect of uric acid on endothelial function [86]. Cross-sectional data of 1.200 Korean adults failed to show an effect of hyperuricemia on endothelial function/arterial stiffness, as represented by pulse wave velocity [87].…”
Section: Discussionmentioning
confidence: 99%
“…53 CRP is increased among subjects with microvascular angina vs. controls, further supporting a possible role of inflammation and endothelial dysfunction in causing CMD. 54 Patients with increased hsCRP have an attenuated rise in CBF in response to acetylcholine (Ach). 55, 56 Systemic lupus erythematosus is frequently associated with angina and CMD, 57 while prior breast cancer chemotherapy may also be associated with CMD.…”
Section: Pathophysiologymentioning
confidence: 99%
“…(17–23),(24, 25) Preliminary data suggest peripheral endothelial dysfunction may be associated with elevated uric acid levels, however these findings are inconsistent. (24, 25),(26, 27) How uric acid may contribute to CED is unknown.…”
Section: Introductionmentioning
confidence: 99%