Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment

Jong, G.I. de; Weerd, Henk de; Schuurman, T.; Traber, J.; Luiten, P.G.M.

doi:10.1016/0197-4580(90)90003-i

Cited by 51 publications

(51 citation statements)

References 27 publications

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“…Previously we have compared the incidence of microvascular aberrations in aged Wistar rats (30 months of age) and in animals chronically treated with nimodipine from 24 up to 30 months of age and found that such a chronic application of nimodipine significantly reduces the percentage microvessels with deposition products in the aged rat forebrain [10]. The main purpose of the present study was to investigate the effects of a prolonged treatment of nimodipine (24-32 months) on microvascular aberrations in the cortex.…”

Section: Introductionmentioning

confidence: 85%

“…Ageing-related microvascular changes have previously been described [10] and are divided into two major categories. The first category is represented by membranous inclusions within the microvascular basement membrane (Fig.…”

Section: Qualitative Alterations Of Cerebral Microvasculaturementioning

confidence: 99%

“…The inclusions are enclosed by a basement membrane and within the inclusions cytoplasmic elements like, for example, mitochondria can be observed. Mainly due to the ultrastructural position in the microvascular wall these membranous inclusions are generally considered to reflect degenerative stages of pericytes [1,10,23]. The second category are microvascular deposits which include microvascular fibrosis (Fig.…”

Section: Qualitative Alterations Of Cerebral Microvasculaturementioning

confidence: 99%

“…Besides numerous functional changes, morphological anomalies of neuronal, glial and (micro)vascular systems are frequently encountered in the aged CNS. At the ultrastructural level several aberrations of cerebral microvessels have been described in aged mammals [1,9,10,15]. In our previous work we distinguished two main categories of ageing-related microvascular anomalies in the aged rat brain, the first of which is represented by membranous inclusions within the basement membrane [10].…”

Section: Introductionmentioning

confidence: 97%

“…In our previous work we distinguished two main categories of ageing-related microvascular anomalies in the aged rat brain, the first of which is represented by membranous inclusions within the basement membrane [10]. The second category was defined as microvascular deposits [10], which include microvascular fibrosis [9,10,15] and thickening of the basement membrane [8,26].…”

Section: Introductionmentioning

confidence: 99%

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Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application

Jong¹,

Traber²,

Luiten³

1992

Mechanisms of Ageing and Development

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Section: Introductionmentioning

confidence: 85%

Section: Qualitative Alterations Of Cerebral Microvasculaturementioning

confidence: 99%

Section: Qualitative Alterations Of Cerebral Microvasculaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application

Jong¹,

Traber²,

Luiten³

1992

Mechanisms of Ageing and Development

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Stereological Investigation of Age‐Related Changes of the Capillaries in White Matter

Shao

Chen

et al. 2010

The Anatomical Record

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We, for the first time, investigated the age-related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age-related changes of the capillaries in white matter may have important implications for age-related white matter atrophy and age-related cognitive impairments.

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Amiridine (NIK‐247) and cerebrocrast in the alleviation of cholinergic lesion‐induced learning deficit in male rats

Männistö

Kutepova

Leinonen

et al. 1993

Drug Development Research

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Learning of the male rats was impaired by injecting ethylcholine aziridiniurn (AF64A) bilaterally into the basal magnocellular nuclei of Meynert. The performance of the rats in a passive avoidance test and in a one-way active avoidance test was significantly improved by giving a novel acetylcholinesterase inhibitor, amiridine (NIK-247; 9-amino-2,3,5,6,7,8-hexahydro-lH-cyclopenta(b)-quinoline rnonohydrate hydrochloride) after each learning session but not when the drug was given before the sessions. Cerebrocrast, an antagonist of L-type calcium channels, was not effective in either case. Rather it worsened the learning results when given after the sessions of the active avoidance test. The conclusions in the passive avoidance test were hampered by the observed inconsistent effects of cholinotoxin. o 1993 Wiiey-Liss, inc.

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Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment

Cited by 51 publications

References 27 publications

Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application

Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application

Stereological Investigation of Age‐Related Changes of the Capillaries in White Matter

Amiridine (NIK‐247) and cerebrocrast in the alleviation of cholinergic lesion‐induced learning deficit in male rats

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