Microvascular endothelial function in obstructive sleep apnea: Impact of continuous positive airway pressure and mandibular advancement

Trzépizur, Wojciech; Gagnadoux, Frédéric; Ábrahám, Pierre; Rousseau, P.; Meslier, Nicole; Saumet, J. L.; Racineux, Jean-Louis

doi:10.1016/j.sleep.2008.06.013

Cited by 107 publications

(117 citation statements)

References 31 publications

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“…16 Unlike the data on CPAP treatment, 4,9 studies on the effect of MAS treatment on inflammatory and hemostatic parameters are scarce. 17,18 MAS treatment improved the endothelial function despite the presence of residual apneas. 17,18 To our knowledge, there have been no reports on blood coagulation, platelet, and fibrinolysis parameters in OSA patients treated with MAS.…”

Section: Modulation Of Infl Ammatory and Hemostatic Markers In Obstrumentioning

confidence: 88%

“…17,18 MAS treatment improved the endothelial function despite the presence of residual apneas. 17,18 To our knowledge, there have been no reports on blood coagulation, platelet, and fibrinolysis parameters in OSA patients treated with MAS. We hypothesized that MAS therapy produces antithrombotic and anti-inflammatory effects, though less pronounced, similar to those observed during CPAP treatment.…”

Section: Modulation Of Infl Ammatory and Hemostatic Markers In Obstrumentioning

confidence: 88%

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Modulation of Inflammatory and Hemostatic Markers in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Splints: A Parallel, Controlled Trial

Niżankowska-Jędrzejczyk

Almeida

Lowe

et al. 2014

Journal of Clinical Sleep Medicine

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BRIEF SUMMARYCurrent Knowledge/Study Rationale: The aim of our study was to assess the effi ciency of fi brinolysis and its determinants, in particular thrombin activatable fi brinolysis inhibitor (TAFI), in OSA patients, since until now plasminogen activator inhibitor-1 and D-dimer have been the only fi brinolytic parameters studied in this disease. This is the fi rst study to investigate the effects of mandibular advancement splints on hemostasis in OSA patients. Study Impact: The study demonstrates antifi brinolytic mechanisms in OSA patients, largely mediated by increased TAFI. MAS treatment in OSA patients is associated with favorable alterations in hemostasis, including improved fi brinolysis.

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Section: Modulation Of Infl Ammatory and Hemostatic Markers In Obstrumentioning

confidence: 88%

Section: Modulation Of Infl Ammatory and Hemostatic Markers In Obstrumentioning

confidence: 88%

Modulation of Inflammatory and Hemostatic Markers in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Splints: A Parallel, Controlled Trial

Niżankowska-Jędrzejczyk

Almeida

Lowe

et al. 2014

Journal of Clinical Sleep Medicine

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“…The level of circulating MPs in peripheral blood has been reported to be increased in several ischemic diseases [7]. It seems that MPs from activated leukocytes (CD62L_ MPs) are higher in patients with OSA and a positive correlation between circulating levels of CD62L_ MPs and nocturnal hypoxemia severity has been reported [16,17,18]. Nevertheless, other authors studying children with sleep breathing disorders observed that leukocyte CD11b+ MPs and platelet CD41a+ MPs were the microparticles that correlated the best with the apnoea-hypopnea index [19].…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after cpap

et al. 2015

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Study objectivesThis study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. DesignObservational study, before and after CPAP therapy. Setting and PatientsWe studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process. Measurements and results After ConclusionsCPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.

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“…This could be linked to higher oxidative stress [25][26][27], endothelial dysfunction [28][29][30], less nitric oxide production [31], and inflammation [32]. All of these pathophysiological aspects could contribute to a decreased myocardial adaptive response.…”

Section: Discussionmentioning

confidence: 99%

Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea – An oxygenation-sensitive CMR study

Roubille

Fischer

Guensch

et al. 2017

Journal of Cardiology

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Microvascular endothelial function in obstructive sleep apnea: Impact of continuous positive airway pressure and mandibular advancement

Cited by 107 publications

References 31 publications

Modulation of Inflammatory and Hemostatic Markers in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Splints: A Parallel, Controlled Trial

Modulation of Inflammatory and Hemostatic Markers in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Splints: A Parallel, Controlled Trial

Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after cpap

Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea – An oxygenation-sensitive CMR study

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