Microvascular function has no menstrual‐cycle‐dependent variation in healthy ovulatory women

Ketel, I.J.G.; Stehouwer, Coen D.A.; Serné, Erik H.; Poel, Danielle M.; Groot, L.C.P.M.G. de; Kager, Cathrien; Hompes, Peter G.A.; Homburg, Roy; Twisk, Jos W. R.; Smulders, Yvo M.; Lambalk, Cornelis B.

doi:10.3109/10739680903199186

Cited by 43 publications

(33 citation statements)

References 54 publications

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“…Although estrogen is known to have vasodilatory effects in large vessels and the coronary microvasculature in postmenopausal women (11,27,39), acute changes in circulating estrogen levels do not affect microvascular responses in normally cycling premenopausal women (16), in agreement with the finding that E 2 perfusion per se did not change SAT blood flow considerably in the current study. The ethanol O:I ratio did change over time throughout the microdialysis visit; however, there was not a specific effect of E 2 perfusion to change the blood flow response differently between probes.…”

Section: Adipose Tissue Blood Flowsupporting

confidence: 91%

Estradiol effects on subcutaneous adipose tissue lipolysis in premenopausal women are adipose tissue depot specific and treatment dependent

Gavin

Cooper

Raymer

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Estrogen has direct effects within adipose tissue and has been implicated in regional adiposity; however, the influence of estrogen on in vivo lipolysis is unclear. The purpose of this study was to investigate the effect of local 17β-estradiol (E(2)) on subcutaneous adipose tissue (SAT) lipolysis in premenopausal women. In vivo lipolysis (dialysate glycerol) was measured in 17 women (age 27.4 ± 2.0 yr, BMI 29.7 ± 0.5 kg/m(2)) via microdialysis of abdominal (AB) and gluteal (GL) SAT. Glycerol was measured at baseline and during acute interventions to increase lipolysis including local perfusion of isoproterenol (ISO, β-adrenergic agonist, 1.0 μmol/l), phentolamine (PHEN, α-adrenergic antagonist, 0.1 mmol/l), and submaximal exercise (60% Vo(2peak), 30 min); all with and without coperfusion of E(2) (500 nmol/l). E(2) coperfusion blunted the lipolytic response to ISO in AB (E(2) 196 ± 31%, control 258 ± 26%, P = 0.003) but not in GL (E(2) 113 ± 14%, control 111 ± 12%, P = 0.43) adipose tissue. At rest, perfusion of PHEN with ISO did not change dialysate glycerol. Submaximal exercise during ISO + PHEN increased dialysate glycerol in the AB (56 ± 9%) and GL (62 ± 12%) regions. Probes perfused with E(2) during exercise and ISO + PHEN had an increased lipolytic response in AB (90 ± 9%, P = 0.007) but a lower response in GL (35 ± 7%, P = 0.05) SAT compared with no-E(2) conditions. E(2) effects on lipolysis are region specific and may work through both adrenergic and adrenergic-independent mechanisms to potentiate and/or blunt SAT lipolysis in premenopausal women.

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Section: Adipose Tissue Blood Flowsupporting

confidence: 91%

Estradiol effects on subcutaneous adipose tissue lipolysis in premenopausal women are adipose tissue depot specific and treatment dependent

Gavin

Cooper

Raymer

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…For comparison, values in postmenopausal women and men are given. Estradiol reaches a mid-cyclic peak (days [8][9][10][11][12][13][14] and gradually declines afterwards, whereas progesterone steeply increases in the second half of the menstrual cycle. Follicle-stimulating hormone and luteinizing hormone both show a mid-cyclic peak and decrease afterwards.…”

Section: Resultsmentioning

confidence: 97%

“…Similarly, changes in vascular function and reactivity of the brachial artery during the menstrual cycle have repeatedly been demonstrated in small cohorts of patients [9]. Less is known on microvascular function [for instance as measured by peripheral arterial tonometry (PAT) [10]] in relation to hormonal during the menstrual cycle, and findings from small patient groups are controversial [11,12].…”

Section: Introductionmentioning

confidence: 98%

Sex differences in noninvasive vascular function in the community

Schnabel

Biener²,

Wilde

et al. 2013

Journal of Hypertension

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“…However, data are inconclusive on the effects of the menstrual cycle on vascular function. 42,43 The lack of randomization of the control period may be considered a limitation of the study. Although the study lacked a control group, the control period did not affect arterial function.…”

Section: Discussionmentioning

confidence: 99%

Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

Kingsley

Figueroa

2011

J Hum Hypertens

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The vascular responses to acute resistance exercise and resistance exercise training (RET) in overweight women are unclear. Therefore, the purpose of this study was to examine the vasodilatory and wave reflection responses to acute resistance exercise before and after RET. In all, 24 overweight/obese (28.5 ± 0.6 kg m À2 ) women (44 ± 1 years of age) volunteered for this study. Forearm blood flow (FBF), vasodilatory capacity in response to reactive hyperemia (peak FBF) and wave reflection (radial tonometry) were measured, before and 15 min after five sets of leg press at 10-repetition maximum (RM). Measures of pulse wave reflection included the augmentation index (AIx) and the time of the reflected wave (Tr). Measurements were collected at baseline, after a 4-week control period (before RET) and after 12 weeks of whole-body RET using three sets of five exercises at 50-60% of 1-RM. There were no differences in vascular measurements at baseline or before RET for any variable. Resting FBF (66.7%) and peak FBF (51.6%) increased significantly (Po0.05) after RET compared with before RET. Postexercise FBF (48.9%) and peak FBF (41.1%) also increased significantly (Po0.05) after RET compared with before RET. Post-exercise AIx decreased significantly (Po0.05), whereas Tr increased significantly (Po0.05) compared with rest at all time points. However, AIx and Tr were unaltered by RET. The 12-week wholebody RET increased the resting and post-exercise FBF as well as vasodilatory capacity without changing wave reflection in premenopausal overweight women. RET may be an important non-pharmacological therapy for reducing cardiovascular risk in overweight and obese premenopausal women.

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Microvascular function has no menstrual‐cycle‐dependent variation in healthy ovulatory women

Abstract: Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation.

Cited by 43 publications

References 54 publications

Estradiol effects on subcutaneous adipose tissue lipolysis in premenopausal women are adipose tissue depot specific and treatment dependent

Estradiol effects on subcutaneous adipose tissue lipolysis in premenopausal women are adipose tissue depot specific and treatment dependent

Sex differences in noninvasive vascular function in the community

Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women

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