Microvascular imaging of the skin

Deegan, Anthony J.; Wang, Ke

doi:10.1088/1361-6560/ab03f1

Cited by 78 publications

(59 citation statements)

References 199 publications

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“…The studies that have assessed graft healing were typically invasive or employed the use of animal models (6,9,12), or measured superficial parameters, such as graft contraction (10), or re-epithelialization (11). Notwithstanding the considerable improvements made in the availability and applicability of modern, non-invasive imaging technologies (13), the imaging and assessment of human skin autograft subsurface structure and vasculature during the integration process remains underexplored and underutilized.…”

Section: Introductionmentioning

confidence: 99%

Imaging human skin autograft integration with optical coherence tomography

Deegan¹,

Lu²,

Sharma³

et al. 2021

Quant Imaging Med Surg

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Background: Skin autografting is a common clinical procedure for reconstructive surgery. Despite its widespread use, very few studies have been conducted to non-invasively evaluate and monitor the vascular and structural features of skin grafts. This study, therefore, aims to demonstrate the potential of optical coherence tomography (OCT) alongside OCT-based angiography (OCTA) to non-invasively image and monitor human skin graft health and integration over time.Methods: An in-house-built clinical prototype OCT system was used to acquire OCT/OCTA images from patients who underwent split-thickness skin graft surgery following severe burn damage to the skin. The OCT imaging was carried out at multiple locations over multiple time points with a field of view of ~9 mm × 9 mm and a penetration depth of ~1.5 mm. In addition to obtaining high-resolution qualitative images, we also quantitatively measured and compared specific structural and vascular parameters, such as identifiable layer thickness and corresponding vascular area density and diameter.Results: Two patients (patient #1 and #2) were enrolled for this preliminary study. Vascular and structural features were successfully imaged and measured in the graft tissue and integration layer immediately beneath at different time points. Revascularization, healing, and integration were monitored with patient-specific details. Results of the quantitative image analysis from patient #1 indicated that integration layer thickness 16-day post-surgery was significantly less (~50%) than that of 7-day post-surgery. Additionally, with patient #2, significant growth (~20%) was seen with the vascular area density of both the graft and corresponding integration layer beneath between 6 and 14 days post-surgery. Conclusions:Our preliminary studies show that OCT/OCTA has clinical potential to image and measure numerous features of human skin graft health and integration in the days and weeks following split-thickness surgery. For the first time, we demonstrate the applicability of non-invasive imaging technology for novel clinical uses that could eventually aid in the betterment of surgical practices and clinical outcomes.

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Section: Introductionmentioning

confidence: 99%

Imaging human skin autograft integration with optical coherence tomography

Deegan¹,

Lu²,

Sharma³

et al. 2021

Quant Imaging Med Surg

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“…DM has a remarkable capacity for adaptation to its cellular environment and continuous interaction with the systemic circulation [13]. DM is essential for the maintaining of skin homeostasis and includes different types of vessels, such as arterioles (from 17 to 26 µm in diameter), meta-arterioles (10 to 20 µm), capillaries (8 to 10 µm), and venules [14].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…With its recent functional extension, OCT angiography (OCTA), 10 the cutaneous microvasculature can be imaged using the flow of red blood cells as a contrast agent 10,11 . Though other methods exist to measure the cutaneous microvasculature, such as Laser Doppler Perfusion Imaging and Laser Speckle Contrast Imaging, these methods only provide a single measurement for perfusion in a region of tissue 12 . By capturing three‐dimensional images of the microvasculature, OCTA can provide rich data where several characteristics can be assessed.…”

Section: Introductionmentioning

confidence: 99%