Microvascular studies in human radiation bowel disease.

Radiation Bowel Disease

“…[35] in their angiographic study demon strated reduced vascularity many months and years after therapeutic irradiation. The microradiographic findings from a recent study support this observation and indicate that severe alterations in microvascular ar chitecture are present in human radiation bowel disease [37],…”

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

“…Leakage of contrast media from injured vessels has also been demonstrated at this stage (127). Later on, angiography shows evidence of degenerative and obliterative changes (SO, 127,128).…”

“…Various angiographic techniques have been used to demonstrate vascular alterations in the intestine following irradiation (SO, [127][128][129]. The angiographic picture is generally consistent with the morphologic alterations at different times after exposure.…”

“…Hence, the net result may be a decrease in capillary filtration (133). At later times, the reduction in capillary filtration is a consequence of perivascular fibrosis (134), and the microvascular volume is significantly reduced because of occlusive changes (128).…”

Anastomotic Blood-Flow Reduction in Rat Small Intestine with Chronic Radiation Damage

“…The mechanisms responsible for the impaired anastomotic healing have never been fully elucidated, although it has been suggested that a reduced local blood supply might be the primary cause [1,3]. This is supported by the observation of thrombi of arterioles and occlusion of capillaries [5] leading to local blood flow reduction in previously irradiated intestine [5,6]. Similar observations have also been made in experimental radiation damage [7][8][9][10][11][12], although some authors report only transient early blood flow reduction [7,8] while others have found an incomplete revascularisation to occur with radiation doses up to 20 Gy [11,12].…”